Beyond the Magic Bullet: Current Progress of Therapeutic Vaccination in Multiple Sclerosis

CNS Drugs
Barbara Willekens, Nathalie Cools

Abstract

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS) characterized by neuroinflammation, neurodegeneration and impaired repair mechanisms that lead to neurological disability. The crux of MS is the patient's own immune cells attacking self-antigens in the CNS, namely the myelin sheath that protects nerve cells of the brain and spinal cord. Restoring antigen-specific tolerance via therapeutic vaccination is an innovative and exciting approach in MS therapy. Indeed, leveraging the body's attempt to prevent autoimmunity, i.e., tolerization, focuses on the underlying cause of the disease and could be the key to solving neuroinflammation. In this perspective, antigen-specific vaccination targets only the detrimental and aberrant immune response against the specific disease-associated antigen(s) involved while retaining the capacity of the immune system to respond to unrelated antigens. We review the experimental approaches of tolerance-inducing vaccination in relapsing and progressive forms of MS that have reached the clinical development phase, including vaccination with autologous T cells, autologous tolerogenic dendritic cells, T cell receptor peptide vaccination, altered peptide ligand...Continue Reading

References

Dec 4, 2001·Journal of Neuroimmunology·Y HussienY M Huang
May 3, 2002·Journal of Neurology·Jingwu Z ZhangYing C Q Zang
Feb 12, 2004·Autoimmunity Reviews·Anat Achiron, Mathilda Mandel
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bibiana BielekovaRoland Martin
Aug 3, 2004·Journal of Translational Medicine·Ruggero RidolfiGiuseppe Fiorentini
Sep 29, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A AchironM Mandel
Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·D N BourdetteA A Vandenbark
Mar 19, 2008·Expert Review of Neurotherapeutics·Olaf StüveTodd N Eagar
May 16, 2008·Annals of Neurology·Hideki GarrenUNKNOWN BHT-3009 Study Group
Jul 5, 2008·Journal of the Neurological Sciences·Andreas LutterottiRoland Martin
Oct 28, 2008·The Journal of Allergy and Clinical Immunology·Justin M SkripakRobert A Wood
Dec 23, 2008·Immunology Letters·David C Wraith
Jan 9, 2009·Results and Problems in Cell Differentiation·Danielle M Turley, Stephen D Miller
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pauline VerdijkI Jolanda M de Vries
Sep 1, 2006·Expert Review of Clinical Immunology·Niels HellingsPiet Stinissen
Aug 27, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Halina Bartosik-PsujekJacek Rolinski
Oct 30, 2010·Annals of Neurology·Maciej JuryńczykKrzysztof Selmaj
Dec 18, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nicolas FissoloManuel Comabella
Jul 14, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L Grau-LópezE Martínez-Cáceres
Oct 7, 2011·Neurology·M S FreedmanUNKNOWN MAESTRO-01 Investigators
Oct 6, 2012·BMC Medicine·Tobias Derfuss
Feb 2, 2013·Multiple Sclerosis : Clinical and Laboratory Research·A H NuytsN Cools
Apr 12, 2013·Clinical and Experimental Immunology·C M U Hilkens, J D Isaacs
Jun 7, 2013·Science Translational Medicine·Andreas LutterottiRoland Martin
Jul 3, 2013·JAMA Neurology·Agata WalczakKrzysztof Selmaj
Dec 10, 2013·Immunology Letters·Dalia Raïch-ReguéAngus W Thomson
Nov 19, 2014·CNS Neuroscience & Therapeutics·María José MansillaEva M Martínez-Cáceres
Mar 24, 2015·Neurology. Neuroimmunology and Neuroinflammation·Heather B StreeterDavid C Wraith

❮ Previous
Next ❯

Citations

Apr 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Irati ZubizarretaPablo Villoslada
Jun 4, 2020·Brain Sciences·Olga Kammona, Costas Kiparissides
Mar 4, 2020·Nanoscale·Pingsai LungQuan Li
Jun 14, 2019·Immunology and Cell Biology·Sarah A Richman, Christopher A Hunter
May 21, 2020·Brain Sciences·Athanasios MetaxakisNektarios Tavernarakis
Aug 20, 2021·Therapeutic Advances in Chronic Disease·Jennifer PfeilAlf Hamann
Aug 28, 2021·International Journal of Molecular Sciences·Laura PasseriSilvia Gregori

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01684761
NCT02618902
NCT02903537
NCT02283671
NCT01973491
NCT02057159

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Clinical Pharmacology and Therapeutics
J L Orthmann-Murphy, Peter A Calabresi
Current Drug Targets. Immune, Endocrine and Metabolic Disorders
T ChitnisS J Khoury
Frontiers in Neurology
Danielle E HarlowAugusto A Miravalle
© 2022 Meta ULC. All rights reserved