Beyond the usual suspects: positive attitudes towards positive symptoms is associated with medication noncompliance in psychosis.

Schizophrenia Bulletin
Steffen MoritzAnne Karow

Abstract

Antipsychotic medication represents the treatment of choice in psychosis according to clinical guidelines. Nevertheless, studies show that half to almost three-quarter of all patients discontinue medication with antipsychotics after some time, a fact which is traditionally ascribed to side-effects, mistrust against the clinician and poor illness insight. The present study investigated whether positive attitudes toward psychotic symptoms (ie, gain from illness) represent a further factor for medication noncompliance. An anonymous online survey was set up in order to prevent conservative response biases that likely emerge in a clinical setting. Following an iterative selection process, data from a total of 113 patients with a likely diagnosis of schizophrenia and a history of antipsychotic treatment were retained for the final analyses (80%). While side-effect profile and mistrust emerged as the most frequent reasons for drug discontinuation, 28% of the sample reported gain from illness (eg, missing voices, feeling of power) as a motive for noncompliance. At least every fourth patient reported the following reasons: stigma (31%), mistrust against the physician/therapist (31%), and rejection of medication in general (28%). Approxi...Continue Reading

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Citations

Apr 18, 2016·Psychiatry Research·Johanna SundagTania M Lincoln
Aug 13, 2013·Schizophrenia Research and Treatment·Steffen MoritzChristina Andreou
Dec 3, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Steffen MoritzTania M Lincoln
Jul 18, 2015·Psychology and Psychotherapy·Jacqueline Hayes, Ivan Leudar
Jul 15, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·S MoritzJ Gallinat
Sep 16, 2014·Psychiatry Research·Joséphine ChaixJérôme Favrod
May 20, 2016·European Archives of Psychiatry and Clinical Neuroscience·Steffen MoritzMatthias Nagel
Aug 10, 2016·Journal of Behavior Therapy and Experimental Psychiatry·Steffen MoritzChristina Andreou
Aug 24, 2016·Comprehensive Psychiatry·Tania M LincolnBjörn Schlier
Sep 7, 2016·European Journal of Medicinal Chemistry·Monika MarcinkowskaPrzemyslaw Bienkowski
Nov 8, 2016·Journal of Behavior Therapy and Experimental Psychiatry·Steffen MoritzJeannette Brodbeck
Nov 2, 2017·Scandinavian Journal of Public Health·Mio FredrikssonJonathan Q Tritter
Aug 23, 2018·Qualitative Health Research·Shimon KatzDavid Roe
May 23, 2019·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Hayley AldersonGail Dovey-Pearce
Jan 14, 2020·International Journal of Psychiatry in Clinical Practice·Devvarta Kumar
Jul 18, 2017·Frontiers in Psychiatry·Katherine BerrySandra Bucci
Jun 26, 2018·Schizophrenia Bulletin·Martino Belvederi Murri, Mario Amore
Feb 19, 2021·Psychiatry Research·Tania M LincolnBjörn Schlier
Nov 5, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Fabrice BernaSteffen Moritz
May 6, 2021·International Journal of Environmental Research and Public Health·Wei YuBinggen Zhu
Aug 15, 2021·Neuropsychopharmacology Reports·UNKNOWN Japanese Society of Neuropsychopharmacology

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