Beyond tissue concentrations: antifungal penetration at the site of infection

Medical Mycology
Yanan ZhaoDavid S Perlin

Abstract

Despite advances in antifungal therapy, invasive fungal infections remain a significant cause of morbidity and mortality worldwide. One important factor contributing to the relative ineffectiveness of existing antifungal drugs is insufficient drug exposure at the site of infection. Despite the importance of this aspect of antifungal therapy, we generally lack a full appreciation of how antifungal drugs distribute, penetrate, and interact with their target organisms in different tissue subcompartments. A better understanding of drug distribution will be critical to guide appropriate use of currently available antifungal drugs, as well as to aid development of new agents. Herein we briefly review current perspectives of antifungal drug exposure at the site of infection and describe a new technique, matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging, which has the potential to greatly expand our understanding of drug penetration.

References

May 1, 1995·Antimicrobial Agents and Chemotherapy·F ThalerP Loirat
Jun 1, 1993·Antimicrobial Agents and Chemotherapy·A J FischmanR H Rubin
Nov 8, 1996·Science·M R Emmert-BuckL A Liotta
Dec 31, 1997·Science·R F BonnerL A Liotta
Dec 1, 2001·American Journal of Respiratory Cell and Molecular Biology·W BernhardC F Poets
Mar 30, 1957·Nature·C HEIDELBERGERJ SCHEINER
Sep 25, 2004·Antimicrobial Agents and Chemotherapy·John E ConteElisabeth Zurlinden
May 23, 2007·Expert Opinion on Pharmacotherapy·Nathan P Wiederhold, James S Lewis
Dec 11, 2007·The Journal of Antimicrobial Chemotherapy·Johan W MoutonOtto Cars
Nov 26, 2008·Antimicrobial Agents and Chemotherapy·John E ConteElisabeth Zurlinden
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN Infectious Diseases Society of America
Nov 26, 2009·Antimicrobial Agents and Chemotherapy·Asma LatJames S Lewis
May 5, 2010·Antimicrobial Agents and Chemotherapy·Thomas J WalshJohn E Conte
May 12, 2010·Antimicrobial Agents and Chemotherapy·Fedja FarowskiCarsten Müller
May 1, 2009·Bioanalysis·Paul J TrimMalcolm R Clench
Mar 29, 2011·Journal of Proteomics·György Marko-VargaAkos Végvári
Oct 7, 2011·World Journal of Surgery·Herman Anthony CarneiroEleftherios Mylonakis
Nov 15, 2011·Bioanalysis·Stephen CastellinoDavid Wagner
Jun 30, 2012·Journal of Proteomics·Emrys A JonesLiam A McDonnell
Jul 31, 2012·Journal of Proteomics·Brendan Prideaux, Markus Stoeckli
Dec 21, 2012·Science Translational Medicine·Gordon D BrownTheodore C White
May 24, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sharon C-A ChenUNKNOWN Australia and New Zealand Mycoses Interest Group (ANZMIG) Cryptococcus Study
Jun 22, 2013·The Journal of Antimicrobial Chemotherapy·Angela LoyseThomas S Harrison
Jan 8, 2014·Clinical Microbiology Reviews·Timothy FeltonWilliam W Hope
Oct 8, 2014·Antimicrobial Agents and Chemotherapy·Ryan K ShieldsCornelius J Clancy
Oct 12, 2014·Current Opinion in Infectious Diseases·Maiken C Arendrup, David S Perlin
Jan 27, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Michaela Aichler, Axel Walch
Mar 25, 2015·Journal of the American Society for Mass Spectrometry·Vanessa V PhelanPieter C Dorrestein
Sep 8, 2015·Nature Medicine·Brendan PrideauxVéronique Dartois
Oct 22, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul E VerweijJacques F Meis
Dec 25, 2015·The European Respiratory Journal·David W DenningUNKNOWN European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
Jan 27, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasJack D Sobel
Feb 5, 2016·Rapid Communications in Mass Spectrometry : RCM·John F CahillGary J Van Berkel

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Citations

Sep 5, 2019·Antimicrobial Agents and Chemotherapy·Frederic Lamoth, Dimitrios P Kontoyiannis
Mar 15, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ana Fernández-CruzDimitrios P Kontoyiannis
May 23, 2021·Clinics in Laboratory Medicine·Sankha S Basu, Nathalie Y R Agar
Jul 31, 2021·Expert Review of Anti-infective Therapy·Daniel Echeverria-EsnalSantiago Grau

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.