bFGF enhances the IGFs-mediated pluripotent and differentiation potentials in multipotent stem cells

Growth Factors
Sang-Bum ParkKyung-Sun Kang

Abstract

It has widely been reported that basic fibroblast growth factor (bFGF) promotes proliferation of human stem cells and contributes to the maintenance of their self-renewal capability through repeated replications. In contrast to embryonic stem cells (ESCs), the effects of growth factors on adult stem cells are poorly understood. In human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs), bFGF is associated with an increased number of proliferating cells. Furthermore, expression levels of ESC markers were increased after treatment with bFGF. bFGF also increased the expression of FGFR, which in turn increased expression of insulin-like growth factor (IGFs). Since IGFs exert autocrine and paracrine effects on stem cells, bFGF-mediated release of IGFs from hUCB-MSCs might enhance FGFR1 and IGF1R expression in neighboring cells. These receptors could subsequently regulate the effects of bFGF and IGFs in adult stem cells. These results suggest that positive feedback regulation of bFGF and IGFs leads to proliferation of hUCB-MSCs.

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Citations

Jun 27, 2012·Cell Transplantation·Min-Soo SeoKyung-Sun Kang
Jan 9, 2013·Cell Transplantation·Min-Soo SeoKyung-Sun Kang
Mar 17, 2017·Stem Cells International·Amer YoussefVictor K M Han
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Pei-Chin ChenYen-Hua Huang

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