PMID: 8594536Oct 1, 1995Paper

bFGF promotes functional expression of transient outward currents in cultured neonatal rat ventricular cells

Pflügers Archiv : European journal of physiology
W GuoJ Toyama

Abstract

To investigate the effect of basic fibroblast growth factor (bFGF) on ion channel expressions in developing cardiac cells, a short-term primary culture of ventricular myocytes isolated from day-old newborn rats was established. Functional expressions of the transient outward currents (Ito) were measured by whole-cell voltage-clamp method. Addition of 40 ng/ml bFGF to the serum-free culture medium for 72 hours increased the Ito density without influences on membrane capacitance of the myocytes, an estimate of cell size. bFGF also promoted expressions of the steady-state outward currents. Methyl 2,5-dihydroxycinnamate (3 microM), a tyrosine kinase inhibitor, showed preferential inhibition of the bFGF-stimulated increase in Ito density. These results suggest that bFGF may play a role in regulating ion channel expressions of developing cardiac cells via activation of bFGF receptor tyrosine kinase activity.

References

Jan 1, 1991·Progress in Growth Factor Research·M D Schneider, T G Parker
Nov 1, 1990·The Journal of Physiology·M J Kilborn, D Fedida

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Citations

Aug 3, 2002·Journal of Neurochemistry·Ninna R HolmSøren-Peter Olesen
Feb 24, 2009·Canadian Journal of Physiology and Pharmacology·Mónica GallegoOscar Casis

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