PMID: 22572381May 11, 2012Paper

BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral cancer HSC-3 cells

Biomedical Research
Yunyan WuHiroshi Kijima

Abstract

DEC1 (BHLHE40/Stra13/Sharp2) and DEC2 (BHLHE41/Sharp1) are basic helix-loop-helix (bHLH) transcription factors that are involved in the regulation of apoptosis, cell proliferation, circadian rhythms and the response to hypoxia. We previously showed the functional effects of DEC1 and DEC2 on apoptosis in human breast cancer MCF-7 cells. However, the roles of DEC1 and DEC2 in oral cancer are poorly understood. We examined whether DEC1 and DEC2 are involved in the regulation of apoptosis in human oral cancer HSC-3 and CA9-22 cells. The expression of DEC2 was upregulated by cis-diamminedichloroplatinum (II) (cisplatin: CDDP) treatment in HSC-3 cells, whereas CDDP treatment had little effects on the expression of DEC2 in CA9-22 cells. We showed that DEC2 overexpression inhibits pro-apoptotic factor Bim and inhibits apoptosis induced by CDDP in HSC-3 cells, whereas it had little effects on apoptosis in CA9-22 cells. DEC1 overexpression had little effects on apoptosis induced by CDDP in these cells. We also found that CDDP upregulated the amounts of DEC2 in the nucleus in HSC-3 cells. These results suggest that DEC2 has anti-apoptotic effects on apoptosis induced by CDDP in HSC-3 cells.

References

Feb 28, 1998·The EMBO Journal·L O'ConnorD C Huang
May 9, 2002·Molecular and Cellular Biology·Michela MaraniNicholas R Lemoine
Sep 5, 2002·Nature Reviews. Cancer·Suzanne Cory, Jerry M Adams
Dec 17, 2002·Oncogene·Moran BenharAlexander Levitzki
Jan 22, 2005·The Journal of Biological Chemistry·Frederic LucianoJohn C Reed
Sep 21, 2007·Cell Cycle·Katherine E EwingsSimon J Cook
Feb 1, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Fuyuki SatoHiroshi Kijima
Jul 7, 2009·International Journal of Oncology·Eumorphia G KonstantakouDimitrios J Stravopodis
Aug 14, 2009·Journal of Biochemistry·Fuyuki SatoHiroshi Kijima
Nov 26, 2009·Molecular Cancer Therapeutics·Toru AkiyamaPeter F M Choong
Mar 20, 2010·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yang LiuHiroshi Kijima
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Mar 29, 2011·Medicina oral, patología oral y cirugía bucal·Isaäc van der WaalJan-Willem Coebergh
Apr 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Fuyuki SatoHiroshi Kijima
Apr 21, 2011·The Journal of Pathology·Ujjal K BhawalSadao Sato
May 13, 2011·The Journal of Biological Chemistry·Juan WangGen Sheng Wu

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Citations

Apr 18, 2015·Journal of Experimental & Clinical Cancer Research : CR·Tu HuQingcheng Yang
Apr 21, 2016·Journal of Experimental & Clinical Cancer Research : CR·Baoen JiangHongyan Tian
Nov 16, 2016·Journal of Perinatal Medicine·Ali Ozgur ErsoyNuri Danisman
Sep 24, 2015·Molecular and Cellular Biology·Kazuo AsanomaKiyoko Kato
Feb 25, 2014·Leukemia·E A CoenenM M van den Heuvel-Eibrink
Apr 29, 2016·Molecular Medicine Reports·Zun-Hai ZhouLei Gu
May 13, 2017·Molecular Medicine Reports·Hidenobu SatoHiroshi Kijima
Aug 31, 2018·Cell Death & Disease·Cristina GalloAlessia Ciarrocchi
Jul 14, 2019·Cancer Research·Ayesha A Shafi, Karen E Knudsen
Oct 23, 2020·Clocks & Sleep·Fuyuki SatoYasuteru Muragaki
Feb 10, 2021·Clocks & Sleep·Fuyuki SatoYasuteru Muragaki
Apr 4, 2021·Biology·Juan Alfonso RedondoBenjamin Beck

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