Bi-directional ACET micropump for on-chip biological applications

Electrophoresis
Reza Hadjiaghaie VafaiePhilippe Renaud

Abstract

The ability to control and pump high ionic strength fluids inside microchannels forms a major advantage for clinical diagnostics and drug screening processes, where high conductive biological and physiological buffers are used. Despite the known potential of AC electro-thermal (ACET) effect in different biomedical applications, comparatively little is known about controlling the velocity and direction of fluid inside the chip. Here, we proposed to discretize the conventional electrodes to form various asymmetric electrode structures in order to control the fluid direction by simple switching the appropriate electric potential applied to the discretized electrodes. The ACET pumping effect was numerically studied by solving electrical, thermal and hydrodynamic multi-physic coupled equations to optimize the geometrical dimensions of the discretized system. PBS solutions with different ionic strength were seeded with 1 μm sized fluorescent particles and electrothermally driven fluid motion was observed inside the channel for different electrode structures. Experimental analyses confirm that the proposed micropump is efficient for a conductivity range between 0.1 and 1 S/m and the efficiency improves by increasing the voltage amplit...Continue Reading

References

Jun 6, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A RamosH Morgan
Mar 10, 2007·Journal of Colloid and Interface Science·Antonio RamosAntonio Castellanos
Feb 1, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Misha Marie GregersenHenrik Bruus
Sep 4, 2012·Electrophoresis·Rodrigo Martinez-Duarte
Sep 12, 2012·Electrophoresis·Naoki SasakiHaeng-Boo Kim
Jan 26, 2013·Electrophoresis·Rodrigo Martinez-DuarteAlexandra Ros
Aug 21, 2013·Journal of Bacteriology·Kuang-Lung HsuehTai-huang Huang
Apr 12, 2014·Electrophoresis·Jiří HrdličkaDalimil Snita
Apr 24, 2014·Lab on a Chip·Meltem ElitasPhilippe Renaud
May 27, 2015·Electrophoresis·Stuart J Williams, Nicolas G Green

❮ Previous
Next ❯

Citations

Nov 14, 2017·Electrophoresis·Mohammad R HossanPrashanta Dutta
Nov 14, 2019·Micromachines·Alinaghi SalariColin Dalton
Mar 15, 2019·Biomicrofluidics·Golak KuntiSuman Chakraborty
Jan 12, 2021·Microfluidics and Nanofluidics·Adem Ozcelik, Zeynep Aslan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.