Biadhesive Peptides for Assembling Stainless Steel and Compound Loaded Micro-Containers

Macromolecular Bioscience
Lina ApitiusUlrich Schwaneberg

Abstract

Biadhesive peptides (peptesives) are an attractive tool for assembling two chemically different materials-for example, stainless steel and polycaprolactone (PCL). Stainless steel is used in medical stents and PCL is used as a biodegradable polymer for fabrication of tissue growth scaffolds and drug delivering micro-containers. Biadhesive peptides are composed of two domains (e.g., dermaseptin S1 and LCI) with different material-binding properties that are separated through a stiff peptide-spacer. The peptesive dermaseptin S1-domain Z-LCI immobilizes antibiotic-loaded PCL micro-containers on stainless steel surfaces. Immobilization is visualized by microscopy and field emission scanning electron microscopy analysis and released antibiotic from the micro-containers is confirmed through growth inhibition of Escherichia coli cells.

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Citations

Jan 7, 2021·Biotechnology and Bioengineering·Maximilian NöthUlrich Schwaneberg
Jun 12, 2021·Journal of Colloid and Interface Science·Aisa HosseinnejadSmriti Singh

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