PMID: 9449167Jan 1, 1997Paper

Biafine applied on human epidermal wounds is chemotactic for macrophages and increases the IL-1/IL-6 ratio

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
B CoulombL Dubertret

Abstract

Using a model of pure epidermal wounds in normal human volunteers, we have studied the effects of Biafine emulsion firstly on inflammatory cell migration, vascular permeability and cytokine release during the first 24 h, and secondly on epidermal wound healing by measuring transepidermal water loss from day 1 to day 7. Under these conditions, Biafine does not improve epidermal healing, in contrast to what is observed with bleeding dermoepidermal wounds. Our results suggest that the effects of Biafine are essentially at the dermis level. The analysis of epidermal wound exudates leads to the same conclusion. As a matter of fact, we demonstrated that Biafine is chemotactic for macrophages and increases the IL-1/IL-6 ratio, chiefly by reducing the secretion of IL-6. This study permits to progressively clarify the mode of action of Biafine, that seems to be located at the level of granulation tissue formation and not at the epidermal level.

Citations

Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P PommierX Montbarbon
Sep 24, 2004·Oncology Nursing Forum·Timothy Kost, UNKNOWN Medix Pharmaceuticals Americas, Inc
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A ElliottUNKNOWN Radiation Therapy Oncology Group Trial 99-13
Apr 6, 2004·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Ronen GlesingerLior Rosenberg
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Nov 24, 2004·Southern Medical Journal·Jennifer L HarperEric G Aguero
Aug 9, 2013·Journal of Wound Care·J KottnerU Blume-Peytavi
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Mar 22, 2015·Archives of Dermatological Research·Aimee E KrauszAdam J Friedman
Dec 1, 2007·Veterinary and Comparative Oncology·A K Flynn, D M Lurie
Sep 16, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Benjamin TranGeorge Han

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