Biana: a software framework for compiling biological interactions and analyzing networks.

BMC Bioinformatics
Javier Garcia-GarciaBaldo Oliva

Abstract

The analysis and usage of biological data is hindered by the spread of information across multiple repositories and the difficulties posed by different nomenclature systems and storage formats. In particular, there is an important need for data unification in the study and use of protein-protein interactions. Without good integration strategies, it is difficult to analyze the whole set of available data and its properties. We introduce BIANA (Biologic Interactions and Network Analysis), a tool for biological information integration and network management. BIANA is a Python framework designed to achieve two major goals: i) the integration of multiple sources of biological information, including biological entities and their relationships, and ii) the management of biological information as a network where entities are nodes and relationships are edges. Moreover, BIANA uses properties of proteins and genes to infer latent biomolecular relationships by transferring edges to entities sharing similar properties. BIANA is also provided as a plugin for Cytoscape, which allows users to visualize and interactively manage the data. A web interface to BIANA providing basic functionalities is also available. The software can be downloaded ...Continue Reading

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Citations

Jan 21, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Rebeca Sanz-PamplonaVíctor Moreno
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May 20, 2021·Briefings in Bioinformatics·Ettore MoscaDaniel Remondini

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Methods Mentioned

BETA
interaction predictions

Software Mentioned

MI
APID
UniHI
AP
UniprotAccession
ONDEX
APID2NET
IntAct
iRefIndex
MIPS

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