Biaryl guanidine inhibitors of in vitro HCV-IRES activity

Bioorganic & Medicinal Chemistry Letters
Elizabeth A JeffersonLisa M Risen

Abstract

A structure-activity relationship analysis was carried out on a high-throughput small molecule screening lead for HCV-IRES translation inhibition. The study led to the identification of a guanidine-based structure with low microM inhibitory activity.

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Citations

Oct 22, 2013·Journal of Medicinal Chemistry·Sergey M DibrovThomas Hermann
Jul 28, 2005·Natural Product Reports·Roberto G S Berlinck, Miriam H Kossuga
Oct 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alexander Litovchick, Jack W Szostak
Jun 17, 2016·Wiley Interdisciplinary Reviews. RNA·Thomas Hermann
Jan 15, 2011·Antiviral Chemistry & Chemotherapy·Darrell R Davis, Punit P Seth
Mar 31, 2007·Chembiochem : a European Journal of Chemical Biology·Matthew D Disney, Jessica L Childs-Disney
Jan 23, 2021·RSC Medicinal Chemistry·G PadroniA E Hargrove
Jul 26, 2008·Journal of the American Chemical Society·Matthew D DisneyJessica L Childs-Disney

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