Bias caused by migration in case-control studies of prenatal risk factors for childhood and adult diseases

American Journal of Epidemiology
M E Jones, A J Swerdlow

Abstract

Case-control studies of prenatal risk factors for disease in later life often ascertain cases from within a defined area, trace the birth records of those cases born within the area, and select controls from birth records within the same area. Bias can occur in these studies if the disease risk factors are related to migration from the area. The effects of this bias were examined in a study in Oxfordshire, England. Cases (n = 218) of diabetes in children and young adults born during 1965-1986 were identified from hospital discharges during 1965-1986; controls (n = 753) were selected from livebirths during 1965-1986. By 1987, 219 controls (29.1%) had migrated from Oxfordshire or died. Low maternal parity and high social class were strongly related to migration, more than the other perinatal factors studied. Migration, therefore, could lead to apparent associations of diabetes risk with parity or social class. For a general instance, the authors show how much bias is caused by different degrees of migration and of association between migration and a perinatal risk factor. Examples are given of how migration can produce apparent trends in risk as well as increased or decreased individual relative risks. If more than 25% of control...Continue Reading

Citations

Oct 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·J HendersonL Davidson
Apr 30, 1999·BMJ : British Medical Journal·D J GunnellE Whitley
Jun 21, 2005·Journal of Epidemiology and Community Health·Stavros Petrou, Emil Kupek
Dec 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Daniel V RiordanJulie S E Gilbert
Mar 13, 2002·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·W O Cooper, K Kuhlthau
Mar 15, 2005·Journal of Endocrinological Investigation·F CadarioUNKNOWN Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology
Oct 23, 2010·Molecular Biology and Evolution·Rafael D RosengartenStephen L Dellaporta
Aug 3, 2012·Molecular Biology and Evolution·Andrea Gloria-SoriaLeo W Buss
Jan 20, 2006·Paediatric and Perinatal Epidemiology·Stavros PetrouMichael Goldacre
Aug 10, 1999·Paediatric and Perinatal Epidemiology·A GrahamA J Swerdlow
Apr 4, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·R IevinsM J Goldacre
Feb 16, 1999·The American Journal of Clinical Nutrition·R A Waterland, C Garza

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