PMID: 9310563Oct 6, 1997Paper

Bias in meta-analysis detected by a simple, graphical test

BMJ : British Medical Journal
M EggerC Minder

Abstract

Funnel plots (plots of effect estimates against sample size) may be useful to detect bias in meta-analyses that were later contradicted by large trials. We examined whether a simple test of asymmetry of funnel plots predicts discordance of results when meta-analyses are compared to large trials, and we assessed the prevalence of bias in published meta-analyses. Medline search to identify pairs consisting of a meta-analysis and a single large trial (concordance of results was assumed if effects were in the same direction and the meta-analytic estimate was within 30% of the trial); analysis of funnel plots from 37 meta-analyses identified from a hand search of four leading general medicine journals 1993-6 and 38 meta-analyses from the second 1996 issue of the Cochrane Database of Systematic Reviews. Degree of funnel plot asymmetry as measured by the intercept from regression of standard normal deviates against precision. In the eight pairs of meta-analysis and large trial that were identified (five from cardiovascular medicine, one from diabetic medicine, one from geriatric medicine, one from perinatal medicine) there were four concordant and four discordant pairs. In all cases discordance was due to meta-analyses showing larger ...Continue Reading

Citations

Oct 10, 2007·Archives of Internal Medicine·Jordan DimitrakovJeffrey L Jackson
Sep 12, 2012·Archives of Internal Medicine·Andrew J VickersUNKNOWN Acupuncture Trialists' Collaboration
Apr 25, 2012·Archives of Internal Medicine·Tinh-Hai ColletUNKNOWN Thyroid Studies Collaboration
Jan 12, 2011·Archives of Neurology·Christiane ReitzUNKNOWN Genetic and Environmental Risk in Alzheimer Disease 1 Consortium
May 3, 2006·Archives of General Psychiatry·Raymond L OwnbyDavid Loewenstein
Sep 23, 2010·JAMA : the Journal of the American Medical Association·Nicolas RodondiUNKNOWN Thyroid Studies Collaboration
Aug 19, 2011·JAMA : the Journal of the American Medical Association·Neal D FreedmanChristian C Abnet
Sep 22, 2011·JAMA : the Journal of the American Medical Association·An PanFrank B Hu
Jul 13, 2002·Arthritis and Rheumatism·Fotini B KarassaUNKNOWN FcgammaRIIa-SLE Meta-Analysis Investigators
Dec 24, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Daniel BainbridgeUNKNOWN Evidence-Based Perioperative Clinical Outcomes Research (EPiCOR) Group
Apr 26, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Daniel BainbridgeDavy C Cheng
Feb 9, 2011·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·V Yengopal, S Mickenautsch
Jan 21, 2010·Diseases of the Colon and Rectum·Constantinos SimillisParis P Tekkis
May 25, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Guo-Long ZhangQing Zhou
Feb 14, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Young Ho LeeGwan Gyu Song
Mar 10, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Young Ho LeeGwan Gyu Song
Mar 20, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Young Ho LeeGwan Gyu Song
Mar 20, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Young Ho LeeGwan Gyu Song
May 18, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Young Ho LeeGwan Gyu Song
Jun 19, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kun-Ju ZhuYi-Ming Fan
Aug 2, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Young Ho Lee, Gwan Gyu Song
Dec 2, 2009·International Journal of Public Health·Dolly BaliunasPaul Shuper
Jul 20, 2006·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M K DienerC M Seiler
Oct 6, 2006·Diabetologia·S C LarssonA Wolk

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