Biased hypermutagenesis associated with mutations in an untranslated hairpin of an RNA virus

Journal of Virology
John C McCormack, A E Simon

Abstract

The mutation frequency of Turnip crinkle virus can increase 12-fold without inducing error catastrophe. Lesions in a hairpin repressor frequently reverted and led to second-site alterations biased for specific mutations. These results suggest that the hairpin may also function as an RNA chaperone to properly fold the RNA-dependent RNA polymerase.

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Citations

Oct 7, 2008·Nucleic Acids Research·Stefan E SeemannRolf Backofen
Jun 27, 2008·Journal of Virology·John C McCormackAnne E Simon
Feb 11, 2015·Virus Research·Anne E Simon

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