Abstract
Substudies of the Childhood Asthma Management Program (CAMP Research Group, 1999, 2000) seek to identify patient characteristics associated with asthma symptoms and lung function. To determine if genetic measures are associated with trajectories of lung function as measured by forced vital capacity (FVC), children in the primary cohort study retrospectively had candidate loci evaluated. Given participant burden and constraints on financial resources, it is often desirable to target a sub-sample for ascertainment of costly measures. Methods that can leverage the longitudinal outcome on the full cohort to selectively measure informative individuals have been promising, but have been restricted in their use to analysis of the targeted sub-sample. In this paper we detail two multiple imputation analysis strategies that exploit outcome and partially observed covariate data on the non-sampled subjects, and we characterize alternative design and analysis combinations that could be used for future studies of pulmonary function and other outcomes. Candidate predictor (e.g. IL10 cytokine polymorphisms) associations obtained from targeted sampling designs can be estimated with very high efficiency compared to standard designs. Further, ev...Continue Reading
References
Oct 12, 2000·The New England Journal of Medicine·UNKNOWN Childhood Asthma Management Program Research GroupRobert Zeiger
Jun 20, 2002·Biometrics·Haibo ZhouM C Wang
Sep 17, 2002·Biometrics·Stuart R LipsitzSteven Lipshultz
Jan 30, 2004·Genetic Epidemiology·Helen LyonScott T Weiss
Aug 22, 2006·Biometrics·J M NeuhausC J Wild
Jun 15, 2007·Epidemiology·Haibo ZhouMatthew P Longnecker
Mar 29, 2008·Biostatistics·Jonathan S Schildcrout, Patrick J Heagerty
Nov 28, 2008·Statistics in Medicine·Petra Bůzková, Thomas Lumley
Apr 10, 2009·American Journal of Epidemiology·Norman E BreslowMichal Kulich
Aug 14, 2009·Biometrics·Jonathan S Schildcrout, Paul J Rathouz
Feb 23, 2010·Statistics in Biosciences·Norman E BreslowMichal Kulich
Jan 13, 2011·Statistics in Medicine·Ian R WhiteAngela M Wood
Jan 22, 2011·Biostatistics·Haibo ZhouJianwen Cai
Feb 26, 2011·Statistics in Medicine·Helena Marti, Michel Chavance
Apr 5, 2011·Biometrics·Jonathan S Schildcrout, Patrick J Heagerty
Nov 17, 2011·Statistics in Medicine·Jonathan S SchildcroutPaul J Rathouz
Feb 16, 2013·Biometrics·Jonathan S SchildcroutPatrick J Heagerty
Feb 28, 2014·Biometrics·John M NeuhausRoss Boylan
Citations
Apr 28, 2016·Biometrical Journal. Biometrische Zeitschrift·Zhaoyin ZhuStephen L George
May 13, 2017·Statistics in Medicine·Zhichao SunSung Kyun Park
Mar 16, 2018·Statistics in Medicine·Leila R ZelnickPatrick J Heagerty
Sep 18, 2018·Statistics in Medicine·Ting WangStephen L George
Jun 6, 2019·American Journal of Epidemiology·Jonathan S SchildcroutPatrick J Heagerty
Dec 21, 2019·Statistics in Medicine·Lauren J BeesleyBhramar Mukherjee
Oct 27, 2017·Epidemiology·Jonathan S SchildcroutPatrick J Heagerty
Oct 13, 2020·Lifetime Data Analysis·Jichang YuJianwen Cai
Jun 3, 2021·Statistics in Medicine·Sara SauerSebastien Haneuse