BIASED SAMPLING DESIGNS TO IMPROVE RESEARCH EFFICIENCY: FACTORS INFLUENCING PULMONARY FUNCTION OVER TIME IN CHILDREN WITH ASTHMA

The Annals of Applied Statistics
Jonathan S SchildcroutPatrick J Heagerty

Abstract

Substudies of the Childhood Asthma Management Program (CAMP Research Group, 1999, 2000) seek to identify patient characteristics associated with asthma symptoms and lung function. To determine if genetic measures are associated with trajectories of lung function as measured by forced vital capacity (FVC), children in the primary cohort study retrospectively had candidate loci evaluated. Given participant burden and constraints on financial resources, it is often desirable to target a sub-sample for ascertainment of costly measures. Methods that can leverage the longitudinal outcome on the full cohort to selectively measure informative individuals have been promising, but have been restricted in their use to analysis of the targeted sub-sample. In this paper we detail two multiple imputation analysis strategies that exploit outcome and partially observed covariate data on the non-sampled subjects, and we characterize alternative design and analysis combinations that could be used for future studies of pulmonary function and other outcomes. Candidate predictor (e.g. IL10 cytokine polymorphisms) associations obtained from targeted sampling designs can be estimated with very high efficiency compared to standard designs. Further, ev...Continue Reading

References

Oct 12, 2000·The New England Journal of Medicine·UNKNOWN Childhood Asthma Management Program Research GroupRobert Zeiger
Sep 17, 2002·Biometrics·Stuart R LipsitzSteven Lipshultz
Jan 30, 2004·Genetic Epidemiology·Helen LyonScott T Weiss
Mar 29, 2008·Biostatistics·Jonathan S Schildcrout, Patrick J Heagerty
Nov 28, 2008·Statistics in Medicine·Petra Bůzková, Thomas Lumley
Apr 10, 2009·American Journal of Epidemiology·Norman E BreslowMichal Kulich
Jan 13, 2011·Statistics in Medicine·Ian R WhiteAngela M Wood
Feb 26, 2011·Statistics in Medicine·Helena Marti, Michel Chavance
Nov 17, 2011·Statistics in Medicine·Jonathan S SchildcroutPaul J Rathouz

❮ Previous
Next ❯

Citations

Apr 28, 2016·Biometrical Journal. Biometrische Zeitschrift·Zhaoyin ZhuStephen L George
Mar 16, 2018·Statistics in Medicine·Leila R ZelnickPatrick J Heagerty
Sep 18, 2018·Statistics in Medicine·Ting WangStephen L George
Jun 6, 2019·American Journal of Epidemiology·Jonathan S SchildcroutPatrick J Heagerty
Oct 13, 2020·Lifetime Data Analysis·Jichang YuJianwen Cai
Jun 3, 2021·Statistics in Medicine·Sara SauerSebastien Haneuse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.