Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation.

The Prostate
Tao WangThomas J Fitzgerald

Abstract

Cell adhesion plays an important role in proliferation, metastasis, and tumor growth and may represent a potential vulnerability in treatment of prostate cancer patients. Bicalutamide (Casodex) has been used as an anti-androgen agent for prostate cancer patients during hormone ablation therapy. This study focuses on the effect of Bicalutamide on cell adhesion to fibronectin (FN) in prostate cancer cells. Androgen-dependent LNCaP prostate cancer cells were stimulated with androgen before being irradiated with doses of 0, 5, 10, or 15 Gy. Cell adhesion to fibronectin was then measured to ascertain androgen's role in integrin mediated prostate cancer cell adhesion. Flow cytometry was used to analyze surface expression of integrin subtypes in LNCaP cells. LNCaP cell adhesion to FN was significantly increased by stimulation with androgen when treated with 10 or 15 Gy ionizing radiations but not at 0 or 5 Gy. This increase was inhibited by treatment with Bicalutamide. LNCaP cells exposed to high dose radiation showed an increased expression of alpha(V) and beta(1) integrins in response to androgen treatment while Bicalutamide abolished this effect. Our data show that Bicalutamide inhibits the effect of androgen on cell adhesion to FN...Continue Reading

References

Jul 15, 1977·International Journal of Cancer. Journal International Du Cancer·E Engvall, E Ruoslahti
May 23, 1998·The Journal of Urology·G AusK Pedersen
Aug 15, 2001·Urology·A KirschenbaumA C Levine
May 17, 2002·The Journal of Biological Chemistry·David MasielloSteven P Balk
Jun 28, 2002·Cancer Metastasis Reviews·M FornaroL R Languino
Mar 22, 2003·Lancet·Angelo M DeMarzoJonathan I Epstein
Feb 3, 2004·Journal of Cellular Biochemistry·T J FitzGeraldJoshua Meyer
May 29, 2004·Cancer Treatment and Research·Hira Lal Goel, Lucia R Languino
Aug 23, 2005·The Prostate·Celeste L KremerAnne E Cress
Mar 7, 2006·Journal of Cellular Biochemistry·Scott M Dehm, Donald J Tindall
Dec 1, 2006·Expert Review of Anticancer Therapy·Tanya B DorffJacek Pinski
Sep 22, 2007·Journal of Cellular Physiology·Naved AlamLucia R Languino
Oct 24, 2007·International Journal of Radiation Biology·V SandfortN Cordes
Dec 7, 2007·International Journal of Radiation Biology·Sangita C PawarAnne E Cress
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 3, 2008·Current Opinion in Urology·Robert E Mitchell, Sam S Chang

❮ Previous
Next ❯

Citations

Aug 12, 2014·The Prostate·Constantinos G Broustas, Howard B Lieberman
Sep 30, 2018·Molecular Cancer Research : MCR·Tao WangThomas J FitzGerald

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2022 Meta ULC. All rights reserved