Bicarbonate Concentration, Acid-Base Status, and Mortality in the Health, Aging, and Body Composition Study

Clinical Journal of the American Society of Nephrology : CJASN
Kalani L RaphaelHealth ABC Study

Abstract

Low serum bicarbonate associates with mortality in CKD. This study investigated the associations of bicarbonate and acid-base status with mortality in healthy older individuals. We analyzed data from the Health, Aging, and Body Composition Study, a prospective study of well functioning black and white adults ages 70-79 years old from 1997. Participants with arterialized venous blood gas measurements (n=2287) were grouped into <23.0 mEq/L (low), 23.0-27.9 mEq/L (reference group), and ≥28.0 mEq/L (high) bicarbonate categories and according to acid-base status. Survival data were collected through February of 2014. Mortality hazard ratios (HRs; 95% confidence intervals [95% CIs]) in the low and high bicarbonate groups compared with the reference group were determined using Cox models adjusted for demographics, eGFR, albuminuria, chronic obstructive pulmonary disease, smoking, and systemic pH. Similarly adjusted Cox models were performed according to acid-base status. The mean age was 76 years, 51% were women, and 38% were black. Mean pH was 7.41, mean bicarbonate was 25.1 mEq/L, 11% had low bicarbonate, and 10% had high bicarbonate. Mean eGFR was 82.1 ml/min per 1.73 m(2), and 12% had CKD. Over a mean follow-up of 10.3 years, 1326...Continue Reading

References

Jun 1, 1987·Southern Medical Journal·L E Anderson, W L Henrich
Mar 1, 1971·The Journal of Clinical Investigation·A J BellinghamC Lenfant
Feb 1, 1967·The Journal of Clinical Investigation·J R LitzowE J Lennon
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B Kirschbaum
Aug 24, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F A OrdóñezS Ferrando
Sep 14, 2001·Journal of the American Geriatrics Society·G W WatererUNKNOWN Health ABC Study
Dec 2, 2004·The Journal of Clinical Endocrinology and Metabolism·Lynda FrassettoAnthony Sebastian
Jul 13, 2006·Archives of Internal Medicine·Kirsten Bibbins-DomingoMichael G Shlipak
Aug 26, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Erland LöfbergAnders Alvestrand
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·F John GennariAndrew S Levey
Nov 19, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Csaba P KovesdyKamyar Kalantar-Zadeh
Apr 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Samir N ShahMichal L Melamed
Jul 18, 2009·Journal of the American Society of Nephrology : JASN·Ione de Brito-AshurstMuhammad M Yaqoob
Dec 17, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Wildon R Farwell, Eric N Taylor
Feb 27, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Charumathi SabanayagamE Shyong Tai
May 24, 2011·PloS One·Aoife O'DonovanUNKNOWN Health Aging and Body Composition Study
Jun 11, 2011·American Journal of Nephrology·Hwee-Yeong NgChien-Te Lee
Sep 3, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Sankar D NavaneethanJoseph V Nally
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Oct 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Judith BuehlmeierMartina Heer
Jan 26, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kalani L RaphaelSrinivasan Beddhu
Mar 16, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mirela DobreUNKNOWN CRIC Investigators
Jun 24, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leonard GoldensteinUNKNOWN Health ABC Study Investigators
Jun 24, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Todd H DriverJoachim H Ix

❮ Previous
Next ❯

Citations

Oct 26, 2016·Urolithiasis·Ethan B FramJoshua M Stern
Apr 5, 2017·Nutrients·Sho HasegawaReiko Inagi
May 16, 2017·Nutrients·Jacek RyszAnna Gluba-Brzózka
Nov 28, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wei ChenJoachim H Ix
Dec 3, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Premraj RajkumarJennifer L Pluznick
Feb 6, 2017·Physiological Reviews·I David Weiner, Jill W Verlander
Mar 24, 2017·American Journal of Physiology. Renal Physiology·Hyun-Wook LeeI David Weiner
Mar 22, 2018·American Journal of Physiology. Renal Physiology·Autumn N HarrisI David Weiner
Apr 11, 2018·American Journal of Physiology. Renal Physiology·Lijuan FangI David Weiner
Aug 22, 2018·Journal of Cellular Biochemistry·Tomohiro OsanaiKen Okumura
Feb 28, 2018·Journal of the American Society of Nephrology : JASN·Autumn N HarrisI David Weiner
Feb 28, 2018·Journal of the American Society of Nephrology : JASN·Hyun-Wook LeeI David Weiner
Mar 24, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Mirela DobreUNKNOWN SPRINT Research Group
Mar 30, 2017·Journal of the American Society of Nephrology : JASN·Kalani L Raphael, Fuad S Shihab
Nov 4, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Kalani L RaphaelJoachim H Ix
Sep 5, 2018·The British Journal of Nutrition·Sarah A ElliottUNKNOWN ENRICH Study Team
Aug 2, 2018·American Journal of Physiology. Renal Physiology·Premraj Rajkumar, Jennifer L Pluznick
Nov 5, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·François BrazierFrank Bienaimé
Feb 1, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Donald E Wesson
Mar 3, 2020·American Journal of Physiology. Renal Physiology·Autumn N HarrisI David Weiner
Jul 2, 2016·Current Opinion in Nephrology and Hypertension·I David Weiner, Jill W Verlander
Mar 28, 2017·Current Diabetes Reports·Pascale Khairallah, Julia J Scialla
Mar 27, 2018·Journal of Cellular Biochemistry·Tomohiro OsanaiKen Okumura
Aug 8, 2019·American Journal of Physiology. Renal Physiology·Autumn N HarrisI David Weiner
Mar 13, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mirela DobreUNKNOWN SPRINT Research Group
Nov 11, 2020·Journal of the American Geriatrics Society·Shilpa SharmaJoachim H Ix
Nov 6, 2018·Journal of Molecular and Cellular Cardiology·Tomohiro OsanaiKen Okumura
Jun 1, 2021·Canadian Journal of Gastroenterology & Hepatology·Michael SchopisSamuel Sigal
Aug 18, 2021·Kidney Medicine·Douglas C Lambert, Matthew K Abramowitz
Jun 6, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Jeffrey A Kraut, Kalani L Raphael
Sep 27, 2021·Clinical Pharmacology and Therapeutics·Julie BeaumeUNKNOWN Club des Jeunes Néphrologues
Oct 5, 2021·American Journal of Physiology. Renal Physiology·Autumn N HarrisI David Weiner
Oct 17, 2017·Advances in Chronic Kidney Disease·Jeffrey A Kraut, Nicolaos E Madias

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.