PMID: 12040490Jun 1, 2002Paper

Biclonal gammopathy associated with immunoglobulin A in a dog with multiple myeloma

Veterinary Clinical Pathology
Shashi K RamaiahR E Raskin

Abstract

A 10-year-old neutered male Airedale Terrier was evaluated for inappetance, weight loss, and lameness. Multiple myeloma was diagnosed based on bone marrow plasmacytosis, multiple lytic bone lesions, and hyperglobulinemia with a clonal gammopathy on serum protein electrophoresis. Splenic plasmacytosis, and retinal lesions consistent with hyperviscosity syndrome also were found. Temporary responses to 2 different chemotherapy protocols (melphalan and prednisone, and cyclophosphamide and prednisone) were seen, with remission of clinical signs and a decrease in the biclonal gammopathy but no resolution of the splenic mass. Eventual return of clinical signs led to euthanasia at 175 days postdiagnosis. Necropsy examination confirmed multiple myeloma involving bone marrow and spleen, and glomerulonephritis. An immunoglobulin-A (IgA) gammopathy was demonstrated by immunoelectrophoresis; biclonality was ascertained by immunofixation electrophoresis. The clonal components consisted of intact Ig with heavy chain of the alpha class and light chain of an undetermined class. To our knowledge, this is the first report of undimerized biclonal gammopathy in a dog caused by a single heavy chain class involving IgA.

References

Mar 1, 1986·Veterinary Pathology·R M JacobsM L Wellman
Dec 1, 1981·The American Journal of Medicine·R A KyleJ A Katzmann
Nov 1, 1995·Veterinary Immunology and Immunopathology·H KatoA Hasegawa
Jan 1, 1997·Journal of the American Animal Hospital Association·E N Peterson, A C Meininger
Aug 19, 2000·Hematology/oncology Clinics of North America·S D RamseyN Urban

❮ Previous
Next ❯

Citations

Jan 28, 2009·Veterinary Clinical Pathology·Chelsea D TrippTamara B Wills
Nov 3, 2010·Veterinary Clinical Pathology·Roberto Vailati FacchiniPaola Roccabianca
Oct 26, 2010·Veterinary Clinical Pathology·Davis M SeeligPaul R Avery
Nov 19, 2011·Veterinary Clinical Pathology·S Zaldívar-LópezC G Couto
Aug 30, 2011·The Journal of Veterinary Medical Science·Shinya FukumotoTsuyoshi Uchide
Oct 11, 2003·The Veterinary Quarterly·Th A M Elsinghorst
Dec 8, 2015·The Journal of Veterinary Medical Science·Masaya IgaseMasaru Okuda
Aug 12, 2017·Veterinary Ophthalmology·Nathaniel P Violette, Eric C Ledbetter
Jun 1, 2005·Veterinary and Comparative Oncology·F GentiliniP Famigli Bergamini
Aug 15, 2019·Veterinary Clinical Pathology·Adam Dugger HarrisA Russell Moore
Jul 5, 2019·Veterinary Clinical Pathology·A Russell Moore, Paul R Avery

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

The Veterinary Clinics of North America. Small Animal Practice
Heather C Workman, William Vernau
Journal of Comparative Pathology
E A MahaffeyS A Brown
© 2021 Meta ULC. All rights reserved