Bicontinuous cyclosporin a loaded water-AOT/Tween 85-isopropylmyristate microemulsion: structural characterization and dermal pharmacokinetics in vivo

Journal of Pharmaceutical Sciences
Hongzhuo LiuSanming Li

Abstract

Topical delivery of Cyclosporin A (CysA) is of great interest for the treatment of autoimmune skin disorders. Microemulsion systems prepared by AOT/Tween85/isopropyl myristate (IPM)/water possessing a potentially improved skin bioavailability of CysA were designed. The structure of microemulsions was investigated by diffusion-ordered NMR spectroscopy (DOSY) and differential scanning calorimetry (DSC) measurements. The DOSY measurements indicated the presence of bicontinuous and water-in-oil microemulsions depending on microemulsion composition. The DSC measurement confirmed that the microemulsion containing 30.0 wt% water was bicontinuous type, in agreement with the DOSY findings. We also evaluated the therapeutic advantage of dermal administration of CysA in rat model. Local (subcutaneous and skin), systemic concentrations and organ distribution (liver and kidney) were evaluated serially following topical and oral application of the drug. In rat dermal applied with the bicontinuous microemulsion containing CysA, the deposition of the drug into skin and subcutaneous fat was respectively almost 30 and 15-fold higher than the concentrations compared with oral administration. Systemic distribution in blood, liver and kidney was mu...Continue Reading

References

May 1, 1995·Journal of Pharmaceutical Sciences·H K ChoiG L Amidon
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·S WangT R Krishnan
Sep 13, 2002·Journal of Pharmaceutical Sciences·Anna Rita BiliaGareth A Morris
Dec 4, 2002·Advanced Drug Delivery Reviews·Mads Kreilgaard
Apr 10, 2004·International Journal of Pharmaceutics·Ramesh R BoinpallyBhaskara R Jasti
Apr 26, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Luciana B LopesM Vitória L B Bentley
Aug 10, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Thomas HultschJonathan Spergel
Jan 28, 2006·International Journal of Pharmaceutics·Hongzhuo LiuYan Zhang

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Citations

Mar 5, 2014·Pharmaceutics·Luciana B Lopes
Feb 15, 2011·Journal of Pharmaceutical Sciences·Lei WangBaoan Yao
Jul 24, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rania M Hathout, Ahmed H Elshafeey
May 15, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rania M Hathout, Timothy J Woodman
Mar 23, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rania M HathoutRichard H Guy
Sep 4, 2013·Pharmaceutical Development and Technology·Sandra Elisa HaasTeresa Dalla Costa
Oct 4, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maria LaptevaYogeshvar N Kalia
Jun 24, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Rania M Hathout, Timothy J Woodman
Aug 30, 2019·Nanomaterials·Abderrazzaq EssaghraouiSalette Reis
Jan 13, 2021·Dermatologic Therapy·Saman Ahmad NasrollahiAlireza Firooz
Feb 15, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Evangelia D TzikaAristotelis Xenakis
Mar 26, 2014·Biomacromolecules·Alice W Du, Martina H Stenzel
Sep 23, 2021·Drug Delivery and Translational Research·Sonia PandeyJitendra Singh Yadav

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