Bicuspid aortic valve is heritable

Journal of the American College of Cardiology
Linda H CripeD Woodrow Benson

Abstract

Previous studies have established familial clustering of bicuspid aortic valve (BAV), presumably indicating genetic inheritance. Our objective was to statistically test whether the segregation pattern of BAV is consistent with genetic inheritance and to obtain an estimate of the size of the genetic effect (heritability). Bicuspid aortic valve occurs in 1% of the population, making it the most common cardiovascular malformation (CVM). Bicuspid aortic valve is frequently an antecedent to aortic valve stenosis or insufficiency and is often associated with other CVMs, including aortic root dilation. The genetic and developmental significance of these findings remains obscure. In 50 probands with BAV, we obtained a three-generation family history and echocardiograms on first-degree relatives. Heritability (h2) of BAV and BAV and/or other CVMs were estimated using maximum-likelihood-based variance decomposition extended to dichotomous traits implemented in the computer package Sequential Oligogenic Linkage Analysis Routines (SOLAR, San Antonio, Texas). A total of 309 probands and relatives participated. Bicuspid aortic valve was identified in 74 individuals (prevalence = 24%). A total of 97 individuals had BAV and/or other CVM (preva...Continue Reading

References

Dec 1, 1978·British Heart Journal·R EmanuelO Feizi
Dec 1, 1976·Journal of Medical Genetics·A R Boon, D F Roberts
Feb 1, 1992·Journal of the American College of Cardiology·R T HahnR B Devereux
Mar 1, 1991·Journal of the American College of Cardiology·C S Roberts, W C Roberts
Apr 1, 1991·The American Journal of Cardiology·R T PachulskiK L Chan
Dec 1, 1989·American Journal of Diseases of Children·J I BrennerJ A Boughman
Jul 1, 1970·The American Journal of Cardiology·W C Roberts
Oct 1, 1982·Annals of Human Genetics·J L Hopper, J D Mathews
Feb 15, 1994·The American Journal of Cardiology·B N Glick, W C Roberts
Apr 24, 1996·American Journal of Medical Genetics·M ClementiR Tenconi
Dec 31, 1997·Journal of the American College of Cardiology·K HuntingtonK L Chan
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C C Lamas, S J Eykyn
Mar 4, 2000·Pediatrics in Review·G Mack, M Silberbach
Aug 21, 2002·Circulation·Paul W M FedakJagdish Butany
Oct 10, 2002·Cardiology Clinics·D Woodrow Benson
Jul 10, 2003·Echocardiography·Cindy BrownDalane W Kitzman

❮ Previous
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Citations

Dec 25, 2009·Pediatric Cardiology·D Woodrow Benson
Mar 15, 2012·Current Atherosclerosis Reports·Guillaume Jondeau, Catherine Boileau
Aug 27, 2013·Current Treatment Options in Cardiovascular Medicine·Amy SchimkeJeffrey Kuvin
Apr 23, 2013·Cell Biochemistry and Biophysics·Luigi Michele Pavone, Russell A Norris
Feb 24, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ahmet Okay Caglayan, Munis Dundar
Jul 19, 2005·Nature·Vidu GargDeepak Srivastava
May 25, 2007·Nature Clinical Practice. Cardiovascular Medicine·James E Davies, Thoralf M Sundt
Apr 8, 2006·Current Opinion in Cardiology·Vidu Garg
Aug 13, 2013·Dimensions of Critical Care Nursing : DCCN·Mary T Quinn GriffinChris Winkelman
Apr 7, 2007·Current Opinion in Cardiology·Husam M Abdel-Qadir, Douglas S Lee
Apr 7, 2007·Current Opinion in Cardiology·Constance G Weismann, Bruce D Gelb
Jan 28, 2010·Current Opinion in Cardiology·Pietro Bajona, Christopher M Feindel
May 19, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Cordelia J BarrickDavid W Threadgill
Sep 3, 2009·Physiological Genomics·Tatiana V TkatchenkoAndrei V Tkatchenko
Feb 16, 2013·Circulation Research·UNKNOWN Pediatric Cardiac Genomics ConsortiumEllen Rosenberg
Jun 3, 2011·The Journal of Clinical Investigation·Brigitte LaforestMona Nemer
Mar 19, 2013·BMC Cardiovascular Disorders·Patrick J WarnerGordon S Huggins
Apr 13, 2013·BMC Medical Genetics·Ilenia FoffaMaria Grazia Andreassi
Sep 14, 2011·PLoS Genetics·Julie HussinPhilip Awadalla
Sep 13, 2012·PLoS Genetics·Marc-Phillip HitzGregor Andelfinger
Aug 7, 2009·Future Cardiology·Stephen H McKellar, Thoralf M Sundt
Apr 29, 2006·Journal of Cardiovascular Medicine·Moreno CecconiGian Piero Perna
Jun 6, 2009·Journal of Cardiovascular Medicine·Massimo Lombardi
Feb 21, 2013·Journal of Cardiovascular Medicine·Giuseppe MercuroMarco Bonvicini
Jun 16, 2012·Cardiology Research and Practice·Brigitte Laforest, Mona Nemer
Jul 10, 2013·Future Cardiology·Cammon B ArringtonNeil E Bowles
Dec 1, 2012·Cardiology Research and Practice·Katie L LosennoMichael W A Chu
Jun 12, 2013·Heart and Vessels·Daniel RinnströmBengt Johansson
May 28, 2013·General Thoracic and Cardiovascular Surgery·Yu KawaharaManabu Fukasawa
May 7, 2014·Pediatric Research·Elizabeth M BonacheaVidu Garg
Jun 5, 2014·Human Genetics·Ming LiUNKNOWN National Birth Defect Prevention Study
Aug 12, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Friedrich C Luft
Sep 29, 2011·Annual Review of Pathology·Frederick J Schoen
Apr 20, 2014·Current Cardiology Reports·Stephanie LaHayeVidu Garg

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