Bicyclic Piperidines via [2 + 2] Photocycloaddition.

The Journal of Organic Chemistry
Valeriya ShcherbakovaPavel K Mykhailiuk

Abstract

A synthetic strategy to fused bicyclic piperidines-building blocks for medicinal chemistry-is developed. The key step was an intramolecular [2 + 2]-photocyclization. The photochemical step was performed on a gram scale. Crystallographic analysis of the obtained compounds revealed that they occupy a novel chemical space and can be considered as elongated analogues of 3-substituted piperidines.

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Citations

Jun 25, 2021·The Journal of Organic Chemistry·Vasyl RipenkoPavel K Mykhailiuk

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