Bid-dependent generation of oxygen radicals promotes death receptor activation-induced apoptosis in murine hepatocytes

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Wen-Xing DingXiao-Ming Yin

Abstract

Activation of tumor necrosis factor receptor 1 or Fas leads to the generation of reactive oxygen species, which are important to the cytotoxic effects of tumor necrosis factor alpha (TNF-alpha) or Fas ligand. However, how these radicals are generated following receptor ligation is not clear. Using primary hepatocytes, we found that TNF-alpha or anti-Fas antibody-induced burst of oxygen radicals was mainly derived from the mitochondria. We discovered that Bid--a pro-death Bcl-2 family protein activated by ligated death receptors--was the main intracellular molecule signaling the generation of the radicals by targeting to the mitochondria and that the majority of oxygen radical production was dependent on Bid. Reactive oxygen species contributed to cell death and caspase activation by promoting FLICE-inhibitory protein degradation and mitochondrial release of cytochrome c. For the latter part, the oxygen radicals did not affect Bak oligomerization but instead promoted mitochondrial cristae reorganization and membrane lipid peroxidation. Antioxidants could reverse these changes and therefore protect against TNF-alpha or anti-Fas-induced apoptosis. In conclusion, our studies established the signaling pathway from death receptor eng...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Nov 15, 1996·Genes & Development·K WangS J Korsmeyer
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·J XiangS J Korsmeyer
Jul 10, 1997·Nature·M IrmlerJ Tschopp
Jun 2, 1998·Seminars in Liver Disease·P R Galle, P H Krammer
Jul 29, 1998·Journal of Neurochemistry·A HochmanD Offen
Oct 31, 1998·Oncogene·C Sidoti-de FraisseJ L Vayssière
Aug 27, 1999·Trends in Pharmacological Sciences·M Patel, B J Day
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·G S Salvesen, V M Dixit
Oct 26, 1999·Biochemical and Biophysical Research Communications·Y ShidojiK Yagi
Feb 9, 2000·Journal of Bioenergetics and Biomembranes·J J LemastersB Herman
May 9, 2000·Progress in Lipid Research·M SchlameM L Greenberg
May 10, 2000·Nature Medicine·G Kroemer, J C Reed
May 12, 2000·The American Journal of Medicine·C Rust, G J Gores
Oct 12, 2000·Nature Cell Biology·M LutterX Wang
Mar 30, 2001·The Journal of Biological Chemistry·V MikhailovP Saikumar
Jan 10, 2002·Developmental Cell·Luca ScorranoStanley J Korsmeyer
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Martin OttSten Orrenius
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hidenari NagaiNeil Kaplowitz
Sep 11, 2002·Apoptosis : an International Journal on Programmed Cell Death·M Degli Esposti
Jan 8, 2003·The Journal of Cell Biology·Jean-Ehrland RicciDouglas R Green
Apr 12, 2003·FEBS Letters·Barry Halliwell

❮ Previous
Next ❯

Citations

Oct 4, 2007·Apoptosis : an International Journal on Programmed Cell Death·Wen-Xing DingXiao-Ming Yin
Jun 11, 2008·Apoptosis : an International Journal on Programmed Cell Death·Xiaoying ZhangTimothy R Billiar
Mar 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cecilia Garcia-PerezGyörgy Hajnóczky
Aug 11, 2007·The Journal of Biological Chemistry·Angela K ZimmermannDaniel A Linseman
Mar 20, 2008·The Journal of Biological Chemistry·Luis E Gómez-QuirozSnorri S Thorgeirsson
Apr 14, 2009·Antioxidants & Redox Signaling·Derick HanNeil Kaplowitz
Apr 12, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hong-Min NiWen-Xing Ding
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Carmen Garcia-Ruiz, José C Fernández-Checa
Aug 23, 2011·The Journal of Pharmacology and Experimental Therapeutics·Shuang MeiWen-Xing Ding
Nov 15, 2006·Molecular and Cellular Biology·Xiaoyun ChenXiao-Ming Yin
Nov 19, 2008·Fibrogenesis & Tissue Repair·Erica Novo, Maurizio Parola
Nov 6, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sharon ManleyWen-Xing Ding
Mar 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Li YuMichael Lenardo
Feb 4, 2014·Molecular and Cellular Biochemistry·D González-FloresJ A Pariente
Nov 26, 2011·Free Radical Biology & Medicine·Heather M WilkinsDaniel A Linseman
Dec 8, 2010·Toxicology and Applied Pharmacology·Subhadip GhatakAmal Santra
Jul 28, 2010·Gastroenterology·Wen-Xing DingXiao-Ming Yin
Jul 21, 2009·Free Radical Biology & Medicine·Sanjoy RoychowdhuryLaura E Nagy
Oct 6, 2005·Journal of Cellular and Molecular Medicine·Nikolaus Seiler, Francis Raul
Dec 17, 2004·Journal of Cellular and Molecular Medicine·Wen-Xing Ding, Xiao-Ming Yin
Jul 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andy WullaertRudi Beyaert
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Neil Kaplowitz
Jul 6, 2014·Chemistry and Physics of Lipids·Natalia TsesinAbraham H Parola
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hong-Min NiWen-Xing Ding
Sep 6, 2008·The American Journal of Pathology·Hong-Min NiXiao-Ming Yin
Jun 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hong-Min NiXiao-Ming Yin
Dec 6, 2006·Free Radical Biology & Medicine·Jay RavalKevin E Behrns
Jan 13, 2006·Mitochondrion·Karima BegricheBernard Fromenty
Dec 6, 2005·Journal of Biochemical and Biophysical Methods·M WeisJ Jakubovský
Jul 20, 2005·Molecular and Cellular Neurosciences·Ranjit S ShettyTimothy S McClintock
Jul 5, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chien-Yun HsiangTin-Yun Ho
Jul 31, 2012·Biochemical and Biophysical Research Communications·Wen-Xing DingXiao-Ming Yin
Feb 6, 2007·Journal of Hepatology·Sophie CazanaveDominique Pessayre
Jan 6, 2015·Antioxidants & Redox Signaling·Robert G Salomon, Wenzhao Bi
Apr 1, 2006·Biochimica Et Biophysica Acta·Hannah M Heath-Engel, Gordon C Shore
Oct 8, 2013·The American Journal of Pathology·Hong-Min NiWen-Xing Ding
Oct 26, 2010·Biochimica Et Biophysica Acta·Shi-Hong MaPaul B S Lai
Jul 12, 2011·The American Journal of Pathology·Hyun-Ae EumTimothy R Billiar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis