Bidirectional associative plasticity of unitary CA3-CA1 EPSPs in the rat hippocampus in vitro

Journal of Neurophysiology
D DebanneS M Thompson

Abstract

Associative long-term potentiation (LTP) and depression of compound and unitary CA3-CA excitatory postsynaptic potentials (EPSPs) were investigated in rat hippocampal slice cultures. The induction of LTP with synchronous pairing of synaptic activation and postsynaptic depolarization resulted in an increase in the amplitude of EPSPs to the same absolute level, regardless of whether the input was naive or had been previously depressed by asynchronous pairing of pre- and postsynaptic activity. Saturated LTP of compound and unitary EPSPs was reversed by asynchronous pairing and could be reinduced by synchronous pairing. The likelihood that an action potential in a presynaptic CA3 cell failed to trigger an unitary EPSP in a postsynaptic CA1 cell decreased after induction of associative potentiation and increased after induction of associative depotentiation. These changes in the rate of transmission failures were accompanied by large changes in the amplitude of nonfailure EPSPs. We conclude that the same CA3-CA1 synapses can alternatively undergo associative potentiation and depression, perhaps through opposite changes in a single expression mechanism.

References

Dec 1, 1981·Journal of Neuroscience Methods·B H Gähwiler
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D DebanneS M Thompson

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Citations

Dec 6, 2005·Experimental Brain Research·Christian MellentinHenrik Jahnsen
Mar 30, 2017·Frontiers in Synaptic Neuroscience·Elke EdelmannVolkmar Leßmann
Aug 15, 2018·PLoS Computational Biology·Gaëtan VignoudJonathan D Touboul
Jul 19, 2018·Frontiers in Computational Neuroscience·Alexandre FoncelleLaurent Venance
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Natasa SavićR Anne McKinney
May 29, 2018·Scientific Reports·Yihui CuiLaurent Venance
Dec 14, 1999·Learning & Memory·V Sourdet, D Debanne

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