Bidirectional Causal Connectivity in the Cortico-Limbic-Cerebellar Circuit Related to Structural Alterations in First-Episode, Drug-Naive Somatization Disorder

Frontiers in Psychiatry
Ranran LiWenbin Guo

Abstract

Background: Anatomical and functional deficits in the cortico-limbic-cerebellar circuit are involved in the neurobiology of somatization disorder (SD). The present study was performed to examine causal connectivity of the cortico-limbic-cerebellar circuit related to structural deficits in first-episode, drug-naive patients with SD at rest. Methods: A total of 25 first-episode, drug-naive patients with SD and 28 healthy controls underwent structural and resting-state functional magnetic resonance imaging. Voxel-based morphometry and Granger causality analysis (GCA) were used to analyze the data. Results: Results showed that patients with SD exhibited decreased gray matter volume (GMV) in the right cerebellum Crus I, and increased GMV in the left anterior cingulate cortex (ACC), right middle frontal gyrus (MFG), and left angular gyrus. Causal connectivity of the cortico-limbic-cerebellar circuit was partly affected by structural alterations in the patients. Patients with SD showed bidirectional cortico-limbic connectivity abnormalities and bidirectional cortico-cerebellar and limbic-cerebellar connectivity abnormalities. The mean GMV of the right MFG was negatively correlated with the scores of the somatization subscale of the sy...Continue Reading

References

Mar 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·L R DerogatisA F Rock
Aug 1, 1987·Archives of General Psychiatry·J I EscobarJ M Golding
Feb 1, 1972·Psychological Medicine·S B Eysenck, H J Eysenck
Apr 19, 2000·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Jul 5, 2001·The Australian and New Zealand Journal of Psychiatry·J Garcia-CampayoC Ceballos
Mar 27, 2002·Psychosomatic Medicine·Kurt KroenkeJanet B W Williams
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Jul 13, 2004·Psychiatry Research·Mika HakalaPäivi M Niemi
Nov 25, 2004·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·François Mai
Mar 31, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Kevin W GreveMatthew S Stanford
May 3, 2005·The American Journal of Psychiatry·Richard J BrownMichael R Trimble
Jan 1, 1995·International Journal of Behavioral Medicine·W RiefM M Fichter
Jan 18, 2006·Biological Psychiatry·Sheila C CaetanoJair C Soares
Jan 26, 2006·Brain : a Journal of Neurology·Jeremy D Schmahmann, David Caplan
Jun 9, 2006·Brain : a Journal of Neurology·Maxime GuyeFabrice Bartolomei
Nov 13, 2008·The Cerebellum·Mitchell Glickstein, Karl Doron
May 5, 2009·Neuroscience·B SacchettiP Strata
Dec 9, 2010·Biological Psychology·Nicole R GiulianiJames J Gross
Jun 10, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Murad AtmacaAlperen Kayali
Jun 17, 2011·The Journal of Neuropsychiatry and Clinical Neurosciences·Francis L StevensKatherine H Taber
Oct 15, 2011·Human Brain Mapping·Moritz de GreckGeorg Northoff
May 2, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mohamed L Seghier
Sep 21, 2012·Psychiatry Investigation·Hanefi YildirimAlperen Kayali
Jan 10, 2013·Scientific Reports·Erwin LemcheMary L Phillips
Jun 5, 2013·Journal of Psychosomatic Research·Wilma L ZijlemaJudith G M Rosmalen
Oct 15, 2014·The Australian and New Zealand Journal of Psychiatry·Qinji SuWenbin Guo
Jan 30, 2015·The Cerebellum·Piergiorgio Strata
Mar 19, 2015·Frontiers in Systems Neuroscience·Shruti JapeeLeslie G Ungerleider
Jun 1, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Yan SongWenbin Guo
Apr 15, 2016·Neuroinformatics·Chao-Gan YanYu-Feng Zang

❮ Previous
Next ❯

Software Mentioned

VBM8
REST
Matlab
DPABI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.