Oct 26, 2018

Bidirectional effects of anxiety and anorexia nervosa: A Mendelian randomization study

BioRxiv : the Preprint Server for Biology
E Caitlin LloydMarcus R Munafo

Abstract

Objectives: To assess bidirectional effects of anxiety and anorexia nervosa (AN) phenotypes. Design: Two-sample Mendelian randomization. Setting: Genome-wide association study (GWAS) summary statistics from the Psychiatric Genomics Consortia (PGC), analysis of the UK Biobank sample, and Anxiety Neuro Genetics Study (ANGST) consortium. Participants: European descent participants from the PGC (n = 14,477), UK Biobank (n = 348,219), and ANGST consortium (n = 17,310, and n = 18,186). Main outcome measures: AN diagnosis, worry, anxiety disorder pathology (case-control and quantitative phenotypes). Results: We found evidence of a moderate genetic correlation between worry and AN (Rg = 0.36, SE = 0.05, p < 0.001), and the Mendelian randomization analysis supported a causal influence of worry on AN (OR = 2.14, 95% CI: 1.18 to 3.90, p = 0.01). There was no clear evidence for a causal effect of AN on worry in this study (B = -0.01, 95% CI: -0.03 to 0.02, p = 0.55). There was no robust evidence for a causal influence of anxiety disorders on AN (for case-control anxiety disorder phenotype: OR = 1.02, 95% CI: 0.69, 1.50, p = 0.922; for quantitative anxiety disorder phenotype: OR = 4.26, 95% CI: 0.49, 36.69, p = 0.187). There was no robust e...Continue Reading

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Mentioned in this Paper

Genome-Wide Association Study
Study
Anorexia
Mendelian Randomization Analysis
Evaluation
Participant
palmitoyl glycol chitosan
PGC gene
Genomics
Neuromodulators

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