Apr 24, 2020

Bidirectional pharmacological perturbations of the noradrenergic system differentially affect tactile detection

BioRxiv : the Preprint Server for Biology
J. McBurney-LinHongdian Yang


The brain neuromodulatory systems heavily influence behavioral and cognitive processes. Previous work has shown that norepinephrine (NE), a classic neuromodulator mainly derived from the locus coeruleus (LC), enhances neuronal responses to sensory stimuli. However, the role of the LC-NE system in modulating perceptual task performance is not well understood. In addition, systemic perturbation of NE signaling has often been proposed to specifically target the LC in functional studies, yet the assumption that localized (specific) and systemic (nonspecific) perturbations of LC-NE have the same behavioral impact remains largely untested. In this study, we trained mice to perform a head-fixed, quantitative tactile detection task, and administered an 2 adrenergic receptor agonist or antagonist to pharmacologically down- or up-regulate LC-NE activity, respectively. We addressed the outstanding question of how bidirectional perturbations of LC-NE activity affect tactile detection, and tested whether localized and systemic drug treatments exert the same behavioral effects. We found that both localized and systemic suppression of LC-NE impaired tactile detection by reducing motivation. Surprisingly, while locally activating LC-NE enabled...Continue Reading

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Mentioned in this Paper

CYP2C19 gene
UGT1A1 protein, human
Enzymes, antithrombotic
Cytochrome P-450 CYP2D6
UGT1A1 gene
Objective (Goal)

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