PMID: 7535933Mar 28, 1995Paper

Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms

Proceedings of the National Academy of Sciences of the United States of America
M L BrandiI MacIntyre

Abstract

Nitric oxide (NO) produces rapid osteoclast detachment and contraction in vitro, and this effect is accompanied by a profound inhibition of bone resorption. Work by others has confirmed these findings in vivo: inhibition of NO synthase [NOS; L-arginine, NADPH: oxygen oxidoreductase (NO-forming), EC 1.14.13.39] in normal rats is followed by increased bone resorption reflected by a marked loss in bone mineral density. In our present study, immunocytochemistry and Northern blotting show the presence of the constitutive calcium-sensitive NOS isoform (cNOS) in normal rat osteoclasts and in the human preosteoclast cell line (FLG 29.1). The inducible NOS isoform (iNOS) was also clearly demonstrable in the rat cells especially after treatment with gamma interferon (IFN-gamma) and bacterial wall products [lipopolysaccharide (LPS)], while a basal level of transcript was detected in the untreated human preosteoclast line. However NADPH-diaphorase activity was intense only in neonatal rat osteoclasts attached to bone, perhaps reflecting either enhancement of cNOS activity by calcium or increased amounts of the inducible isoform in activated osteoclasts in situ compared with isolated neonatal rat osteoclasts. These actively resorb devitaliz...Continue Reading

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S LamasT Michel
Sep 4, 1992·Cell·C J Lowenstein, S H Snyder
Feb 1, 1992·Endocrine Reviews·T SudaT J Martin
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·I MacIntyreJ R Vane
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·T P KastenG A Nickols
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A GellerT R Billiar

❮ Previous
Next ❯

Citations

Feb 24, 2011·JAMA : the Journal of the American Medical Association·Sundeep Khosla
Mar 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D M Evans, S H Ralston
Nov 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T KawaseD M Burns
Jan 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·T J Hall, T J Chambers
May 15, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Cesar A OssolaJavier Fernandez-Solari
Apr 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R K RudeJ Kilburn
Sep 19, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A JamalR G Josse
Jan 12, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A JamalC J Hamilton
May 26, 2011·Calcified Tissue International·Hideki KitauraTeruko Takano-Yamamoto
Sep 26, 2006·Odontology·Jemin Kim, Salomon Amar
Jan 3, 2012·Current Osteoporosis Reports·Sophie A Jamal, Celeste J Hamilton
Jul 31, 1999·Experimental Hematology·G D Roodman
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M PerrettiR J Flower
Jul 14, 1998·Bone·S W Fox, J W Chow
Jan 15, 2014·BoneKEy Reports·Celeste J HamiltonSophie A Jamal
Jul 17, 2001·Immunology·R J van't Hof, S H Ralston
Jun 25, 2009·The Journal of Clinical Endocrinology and Metabolism·Sunil J WimalawansaDonald R Hoover
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R J van't Hof, S H Ralston
Mar 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P D Damoulis, P V Hauschka
Jul 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H HelfrichS H Ralston
Jan 27, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P Collin-OsdobyP Osdoby
Nov 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S A JamalS R Cummings
Jan 5, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K E ArmourS H Ralston
Jun 3, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M V HukkanenJ M Polak
Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S J Wimalawansa
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P Collin-OsdobyP Osdoby
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S WimalawansaS Wimalawansa
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·W ZhuG A Murrell
Mar 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Francisco Airton Castro da Rocha, Artur José de Brum-Fernandes
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wei ZhuAshish D Diwan
Nov 2, 2004·Journal of Periodontology·R F C LeitãoG A C Brito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
T P KastenG A Nickols
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
S H RalstonN Benjamin
Proceedings of the National Academy of Sciences of the United States of America
I MacIntyreJ R Vane
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
R J Van'T Hof, S H Ralston
© 2021 Meta ULC. All rights reserved