PMID: 26833154DOI: 10.1128/aac.00007-16Feb 3, 2016Paper
Bidirectional Transfer of Raltegravir in an Ex Vivo Human Cotyledon Perfusion Model
Antimicrobial Agents and Chemotherapy
Cécile VinotLaurent Mandelbrot
Abstract
Placental transfer of the HIV integrase inhibitor raltegravir (RLT) was investigated in term human cotyledons in the maternal-to-fetal (n = 3) and fetal-to-maternal (n = 6) directions. In the maternal-to-fetal direction, the mean ± standard deviation (SD) fetal transfer rate (FTR) was 9.1% ± 1.4%, and the mean ± SD clearance index (IC), i.e., RLT FTR/antipyrine FTR, was 0.28 ± 0.05. In the fetal-to-maternal direction, the mean ± SD CI was 0.31 ± 0.09. Placental transfer of RLT was high in both directions.
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Aug 14, 2019·PloS One·Laurent MandelbrotGilles Peytavin
Nov 8, 2017·AIDS·Valentine Faure-BardonGilles Peytavin
May 1, 2020·PloS One·Valentine Faure BardonYves Ville
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Oct 27, 2020·AIDS·Hugo Soudeyns, Julie Dumond
Jun 22, 2021·The Journal of Antimicrobial Chemotherapy·Minh Patrick LêLaurent Mandelbrot
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