Bidirectional translational research: Progress in understanding addictive diseases.

Neuropharmacology
M J KreekEduardo Butelman

Abstract

The focus of this review is primarily on recent developments in bidirectional translational research on the addictions, within the Laboratory of the Biology of Addictive Diseases at The Rockefeller University. This review is subdivided into major interacting aspects, including (a) Investigation of neurobiological and molecular adaptations (e.g., in genes for the opioid receptors or endogenous neuropeptides) in response to cocaine or opiates, administered under laboratory conditions modeling chronic patterns of human self-exposure (e.g., chronic escalating "binge"). (b) The impact of such drug exposure on the hypothalamic-pituitary-adrenal (HPA) axis and interacting neuropeptidergic systems (e.g., opioid, orexin and vasopressin). (c) Molecular genetic association studies using candidate gene and whole genome approaches, to define particular systems involved in vulnerability to develop specific addictions, and response to pharmacotherapy. (d) Neuroendocrine challenge studies in normal volunteers and current addictive disease patients along with former addicts in treatment, to investigate differential pharmacodynamics and responsiveness of molecular targets, in particular those also investigated in the experimental and molecular g...Continue Reading

References

Jul 3, 1992·Brain Research·E M UnterwaldM J Kreek
Oct 1, 1966·Archives of Internal Medicine·V P DoleM J Kreek
Oct 1, 1972·Annals of Internal Medicine·M J KreekR Martin
Jul 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·Y BursteinC M Peterson
Sep 1, 1993·Brain Research. Molecular Brain Research·R SpanglerM J Kreek
Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·S D SchlussmanM J Kreek
Dec 1, 1999·Journal of the American Medical Informatics Association : JAMIA·P M NadkarniP Miller
Apr 3, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H SchlugerM J Kreek
Nov 15, 2001·Current Psychiatry Reports·G O'LearyR D Weiss
May 6, 2003·The Journal of Pharmacology and Experimental Therapeutics·Gavin BartMary Jeanne Kreek
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Stefan D SchlussmanMary Jeanne Kreek
Jun 6, 2003·The European Journal of Neuroscience·P FagergrenY L Hurd
Jun 19, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David W OslinCharles P O'Brien
Mar 6, 2004·Neuromolecular Medicine·Mary Jeanne KreekK Steven LaForge
Nov 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gavin BartMarkus Heilig
Mar 1, 2005·Pharmacological Reviews·Mary Jeanne KreekDavid A Nielsen
Jul 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gavin BartMary Jeanne Kreek
Jul 28, 2005·The Journal of Biological Chemistry·Ying ZhangWolfgang Sadée
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco LeriMary Jeanne Kreek
Nov 2, 2005·European Journal of Endocrinology·Nicole ReischMartin Reincke
Mar 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Y ZhangM J Kreek
Apr 7, 2006·Journal of Addictive Diseases·Einat PelesMiriam Adelson
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gavin BartMary Jeanne Kreek

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Citations

Apr 16, 2013·Analytical Chemistry·Christian K FreseA F Maarten Altelaar
Apr 22, 2010·Journal of Addictive Diseases·Mary Jeanne KreekBrenda Ray
Feb 2, 2013·Clinical and Translational Medicine·Holly J Mata, Sharon Davis
Mar 6, 2010·Annals of the New York Academy of Sciences·Vadim YuferovMary Jeanne Kreek
Apr 30, 2015·Addiction Biology·Samantha L WhiteMathieu E Wimmer

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