Bifacial Base-Pairing Behaviors of 5-Hydroxyuracil DNA Bases through Hydrogen Bonding and Metal Coordination

Chemistry : a European Journal
Yusuke TakezawaMitsuhiko Shionoya

Abstract

A novel bifacial ligand-bearing nucleobase, 5-hydroxyuracil (U(OH) ), which forms both a hydrogen-bonded base pair (U(OH) -A) and a metal-mediated base pair (U(OH) -M-U(OH) ) has been developed. The U(OH) -M-U(OH) base pairs were quantitatively formed in the presence of lanthanide ions such as Gd(III) when U(OH) -U(OH) pairs were consecutively incorporated into DNA duplexes. This result established metal-assisted duplex stabilization as well as DNA-templated assembly of lanthanide ions. Notably, a duplex possessing U(OH) -A base pairs was destabilized by addition of Gd(III) ions. This observation suggests that the hybridization behaviors of the U(OH) -containing DNA strands are altered by metal complexation. Thus, the U(OH) nucleobase with a bifacial base-pairing property holds great promise as a component for metal-responsive DNA materials.

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Citations

Jun 25, 2016·International Journal of Molecular Sciences·Yusuke TakezawaMitsuhiko Shionoya
Apr 27, 2016·Chemistry : a European Journal·Dattatraya UkaleTuomas Lönnberg
Nov 21, 2015·Chemistry : a European Journal·Philipp ScharfJens Müller
Jan 27, 2016·Chemical Communications : Chem Comm·Teruki KobayashiMitsuhiko Shionoya
Apr 28, 2018·Angewandte Chemie·Biswarup Jash, Jens Müller
Jun 14, 2018·Chemistry : a European Journal·Biswarup Jash, Jens Müller
Jul 2, 2019·Angewandte Chemie·Shuvankar NaskarJens Müller
Nov 5, 2019·Chemistry : a European Journal·Shuvankar Naskar, Jens Müller
Apr 12, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Biswarup Jash, Jens Müller
Sep 10, 2020·Chemical Communications : Chem Comm·Tatsuya FunaiHidehito Urata
Aug 24, 2017·Chemistry : a European Journal·Biswarup Jash, Jens Müller
Nov 20, 2016·Angewandte Chemie·Soham MandalJens Müller
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jim BachmannNikos L Doltsinis
Feb 23, 2021·Chemical Communications : Chem Comm·Kotaro NishiyamaMitsuhiko Shionoya
Apr 2, 2021·Metallomics : Integrated Biometal Science·Marie FlammeMarcel Hollenstein
Apr 21, 2021·Journal of Inorganic Biochemistry·Isabell SchönrathJens Müller
Dec 19, 2020·Journal of the American Chemical Society·Yusuke TakezawaMitsuhiko Shionoya
Nov 17, 2019·Journal of the American Chemical Society·Yusuke TakezawaMitsuhiko Shionoya

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