Bifenthrin Fatality in a Canine: A Case Report with Postmortem Concentrations

Journal of Analytical Toxicology
John P BuchweitzAndreas F Lehner

Abstract

A case of canine intoxication and fatality with the pyrethroid insecticide bifenthrin is described. A 5-year-old female spayed Pit Bull Terrier was off leash and unsupervised at home for 15-20 min prior to discovery by her owner. The patient was in lateral recumbency, having what the owner described as a seizure. The patient was transported to an emergency veterinary hospital where she presented with tachycardia, tachypnea and intractable tremors/seizures. Despite aggressive medical intervention, the patient went into respiratory and cardiac arrest and died at 28 h after presentation. A postmortem liver sample screened positive for bifenthrin by gas chromatography-mass spectrometry (GC-MS). During the screening procedure, four additional bifenthrin-metabolic products were also observed. Concentrations for bifenthrin were determined for fat, kidney, liver and urine by GC-MS-MS. This is the first reported case of a canine fatality resulting from bifenthrin.

References

Jan 22, 2008·Neurotoxicology and Teratology·M J Wolansky, J A Harrill
Jun 29, 2011·Archives of Toxicology·David M Soderlund
Oct 27, 2011·Care Management Journals : Journal of Case Management ; the Journal of Long Term Home Health Care·UNKNOWN Medicare Rights Center
Aug 16, 2014·Aquatic Toxicology·Breanna C DeGroot, Susanne M Brander
Mar 6, 2018·Chemosphere·John P BuchweitzAndreas Lehner

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Citations

Aug 29, 2020·Toxicology Mechanisms and Methods·Andreas F LehnerDaniel K Langlois
Jul 15, 2020·Rapid Communications in Mass Spectrometry : RCM·Andreas F LehnerJohn P Buchweitz
Jan 22, 2021·Journal of Analytical Toxicology·John P BuchweitzAndreas F Lehner
May 4, 2021·Journal of Analytical Toxicology·John P BuchweitzBirgit Puschner
Sep 29, 2018·Journal of Agricultural and Food Chemistry·John P BuchweitzAndreas F Lehner

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