Bifidobacterial enzymes involved in the metabolism of human milk oligosaccharides.

Advances in Nutrition
Motomitsu Kitaoka

Abstract

Intestinal colonization of bifidobacteria is important for the health of infants. Human milk oligosaccharides (HMO) have been identified as growth factors for bifidobacteria. Recently, a bifidobacterial enzymatic system to metabolize HMO was identified. 1,3-β-Galactosyl-N-acetylhexosamine phosphorylase (GLNBP, EC 2.4.1.211), which catalyzes the reversible phosphorolysis of galacto-N-biose (GNB) (Galβ1→3GalNAc)] and lacto-N-biose I (LNB) (Galβ1→3GlcNAc), is a key enzyme to explain the metabolism of HMO. Infant-type bifidobacteria possess the intracellular pathway to specifically metabolize GNB and LNB (GNB/LNB pathway). Bifidobacterium bifidum possesses extracellular enzymes to liberate LNB from HMO. However, Bifidobacterium longum subsp. infantis imports intact HMO to be hydrolyzed by intracellular enzymes. Bifidobacterial enzymes related to the metabolism of HMO are useful tools for preparing compounds related to HMO. For instance, LNB and GNB were produced from sucrose and GlcNAc/GalNAc in 1 pot using 4 bifidobacterial enzymes, including GLNBP. LNB is expected to be a selective bifidus factor for infant-type strains.

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Citations

Sep 26, 2013·Protein Engineering, Design & Selection : PEDS·Yoshiyuki KoyamaMotomitsu Kitaoka
Mar 12, 2013·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Akira Kobata
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Jun 11, 2021·Frontiers in Immunology·Anaïs RousseauxMarie Bodinier
Jul 29, 2021·Microbial Genomics·Chiara TarracchiniMarco Ventura

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