Bifidobacterium animalis subsp. lactis fails to prevent common infections in hospitalized children: a randomized, double-blind, placebo-controlled study

The American Journal of Clinical Nutrition
Iva HojsakSanja Kolaček

Abstract

The incidence of nosocomial infections in children in developed countries is still high, ranging from 8% to 30%, and standard preventive measures, such as increased hygiene, are not sufficiently efficacious. One of the potential strategies for their prevention is the use of probiotics. The aim of the study was to investigate the role of Bifidobacterium animalis subsp. lactis in preventing nosocomial infections in the acute hospital setting. We conducted a randomized, double-blind, placebo-controlled trial in 727 hospitalized children (aged 1-18 y). The children were randomly allocated to receive placebo (placebo group, n = 365) or B. animalis subsp. lactis at a dose of 10(9) colony-forming units/d (intervention group, n = 362) once daily for the entire duration of the hospital stay. Nosocomial infections were defined as infections that occurred >48 h after hospital admission and that were not present or incubating at the time of admission. Analysis was performed on an intention-to-treat basis. There was no difference in the study primary outcome or incidence of common nosocomial gastrointestinal and respiratory tract infections between groups (22 vs. 29 infections, respectively; incidence rate ratio = 0.76; 95% CI: 0.41, 1.36; ...Continue Reading

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Citations

Oct 27, 2015·Expert Review of Anti-infective Therapy·Carlo CaffarelliGiampaolo Ricci
Apr 7, 2016·Best Practice & Research. Clinical Gastroenterology·Yvan Vandenplas
Mar 19, 2016·Alimentary Pharmacology & Therapeutics·M UrbańskaH Szajewska
Sep 9, 2015·Archives of Disease in Childhood·Hania Szajewska
Nov 10, 2015·The British Journal of Nutrition·Linda V ThomasJia Zhao
Jun 3, 2017·Journal of Pediatric Gastroenterology and Nutrition·Iva HojsakUNKNOWN ESPGHAN Working Group for Probiotics/Prebiotics
Aug 14, 2018·The International Journal of Neuropsychopharmacology·Thomaz F S BastiaanssenJohn F Cryan
Sep 6, 2018·Food & Function·Monique Santos do CarmoValério Monteiro-Neto
May 22, 2018·Journal of Clinical Gastroenterology·Ivana Trivić, Iva Hojsak
Apr 6, 2019·Gut Microbes·Jotham SuezEran Elinav
Jun 19, 2019·The Cochrane Database of Systematic Reviews·Anna M ScottChris B Del Mar
Oct 14, 2017·Pediatric Gastroenterology, Hepatology & Nutrition·Iva Hojsak
Jan 13, 2017·Journal of Pediatric Gastroenterology and Nutrition·Benedikte GrenovKim F Michaelsen
Jun 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sanja KolačekUNKNOWN ESPGHAN Working Group for Probiotics and Prebiotics
Jul 3, 2021·Nutrients·Leontien Depoorter, Yvan Vandenplas

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