Bifidobacterium animalis subspecies lactis modulates the local immune response and glucose uptake in the small intestine of juvenile pigs infected with the parasitic nematode Ascaris suum

Gut Microbes
Gloria Solano-AguilarJ F Urban

Abstract

An evaluation of a localized intestinal allergic type-2 response concomitant with consumption of probiotic bacteria is not well documented. This study investigated the effect of feeding probiotic Bifidobacterium animalis subspecies lactis (Bb12) or a placebo in weaned pigs that were also inoculated with Ascaris suum (A. suum) eggs to induce a strong Th2-dependent allergic type 2 immune response. Sections of jejunal mucosa were mounted in Ussing chambers to determine changes in permeability and glucose absorption, intestine and liver samples were collected for analysis of type-2 related gene expression, jejunum examined histologically, and sera and intestinal fluid were assayed for parasite antigen specific antibody. The prototypical parasite-induced secretory response to histamine and reduced absorption of glucose in the jejunum were attenuated by feeding Bb12 without a change in mucosal resistance. Parasite antigen-specific IgA response in the serum and IgG1 and IgG2 response in the ileal fluid were significantly increased in A. suum-infected pigs treated with Bb12 compared to infected pigs given the placebo. Ascaris suum-induced eosinophilia in the small intestinal mucosa was inhibited by Bb12 treatment without affecting the ...Continue Reading

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Citations

Feb 3, 2019·Applied and Environmental Microbiology·Gabriele Andrea LugliFrancesca Turroni
Aug 23, 2019·Journal of the Science of Food and Agriculture·Yunkun LiXiaogang Du
Oct 11, 2019·Journal of the Science of Food and Agriculture·Surya Chandra Rao Thumu, Prakash M Halami
Jan 1, 2020·Current Protein & Peptide Science·Manyi JiaXi Ma
Feb 20, 2020·Current Protein & Peptide Science·Fei XieHongfu Zhang
Aug 27, 2021·Frontiers in Pharmacology·Maria Priscila SaracinoDaniel Horacio González Maglio

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Methods Mentioned

BETA
PCR
gene array

Software Mentioned

Statview

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