Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury

PloS One
Sabrina DurantiFrancesca Turroni

Abstract

Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jun 1, 1996·The Journal of Small Animal Practice·R M BattA A Sancak
Nov 1, 1996·Trends in Microbiology·R D Berg
Feb 24, 2000·The Journal of Pathology·D L Carden, D N Granger
Jul 9, 2004·Applied and Environmental Microbiology·Miguel GueimondeSeppo Salminen
Feb 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mansour MohamadzadehTodd R Klaenhammer
Mar 26, 2005·Science·Fredrik BäckhedJeffrey I Gordon
Feb 8, 2011·PloS One·Iradj SobhaniJean P Furet
Jun 13, 2012·Journal of Clinical Gastroenterology·Francisco GuarnerUNKNOWN World Gastroenterology Organization
Mar 22, 2013·Cellular and Molecular Life Sciences : CMLS·Francesca TurroniDouwe van Sinderen
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Francesca TurroniMarco Ventura
Nov 19, 2013·Applied and Environmental Microbiology·Francesca TurroniMarco Ventura
Dec 3, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard N FedorakKaren Madsen
Jan 14, 2016·British Journal of Pharmacology·G Aviello, U G Knaus
Mar 27, 2016·Critical Care Clinics·Thomas W CarverAmit Taneja
Sep 9, 2016·FEMS Microbiology Ecology·Sabrina DurantiFrancesca Turroni
Aug 25, 2017·The ISME Journal·Christian MilaniMarco Ventura
Jun 2, 2018·Drug Discovery Today·Simona BertoniMassimiliano Tognolini

❮ Previous
Next ❯

Citations

Nov 4, 2020·Journal of Physiology and Biochemistry·Ghaidafeh Akbari
Mar 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jun WangGuosheng Wu
May 4, 2021·Comprehensive Reviews in Food Science and Food Safety·Jie GaoYaxin Sang
Jun 16, 2021·The Journal of Surgical Research·Özgür İkizTülin Fırat

❮ Previous
Next ❯

Methods Mentioned

BETA
SMA
PCR
MDA

Software Mentioned

Prism
GraphPad
CFX96 Bio - Rad
ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.