Abstract
Psychological stress is associated with gastrointestinal (GI) distress. This secondary analysis from a randomised, double-blind, placebo-controlled study examined whether three different probiotics could normalise self-reported stress-associated GI discomfort and reduce overall self-reported stress. Undergraduate students (n=581) received Lactobacillus helveticus R0052, Bifidobacterium longum ssp. infantis R0033, Bifidobacterium bifidum R0071, or placebo. Participants self-reported 2 outcomes for a 6-week period, which included final academic exams: daily level of stress (0=no stress to 10=extremely stressed) and weekly three diarrhoea-related symptoms (DS, 1=no discomfort to 7=severe discomfort) using the GI Symptom Rating Scale. Self-reported stress was positively related to DS (P=0.0068). Mean DS scores were lower with B. bifidum versus placebo at week 2 at the average level of stress and the average body mass index (BMI). DS scores were lower with B. bifidum at week 5 versus week 0 and 1 and with B. infantis R0033 at week 6 versus week 0. DS scores were higher when antibiotics were used in the prior week with placebo (P=0.0092). DS were not different with or without antibiotic use with the probiotics. Only B. bifidum had an...Continue Reading
References
Apr 1, 1978·British Journal of Pharmacology·R D Rink
Sep 23, 1997·Scandinavian Journal of Gastroenterology·S J Lewis, K W Heaton
Mar 3, 1998·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·D A RevickiJ Crawley
Feb 23, 1999·Gut·K A GweeN W Read
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·C C BeaufourM H Thiébot
Jun 19, 2003·Psychoneuroendocrinology·J GaabU Ehlert
May 5, 2004·Psychological Bulletin·Sally S Dickerson, Margaret E Kemeny
Jan 5, 2005·Pediatrics·Zvi WeizmanAhmed Alsheikh
May 27, 2006·The Lancet Infectious Diseases·Sunil SazawalRobert E Black
Feb 7, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A N VgontzasE O Bixler
Feb 10, 2009·Nutrition·Shunji FujimoriChoitsu Sakamoto
Feb 26, 2010·BioPsychoSocial Medicine·Kaya T IshizawaYasuhiko Iwamoto
Oct 27, 2010·The British Journal of Nutrition·Michaël MessaoudiJean-Marc Cazaubiel
Apr 29, 2011·The American Journal of Clinical Nutrition·Christine HughesBobbi Langkamp-Henken
Jan 12, 2012·Gut·N A KoloskiN J Talley
Apr 12, 2012·Pediatrics·Rina AgustinaIngeborg M J Bovee-Oudenhoven
May 1, 2012·Psychoneuroendocrinology·Afifa Ait-BelgnaouiVassilia Theodorou
May 10, 2012·JAMA : the Journal of the American Medical Association·Susanne HempelPaul G Shekelle
Jan 26, 2013·BMC Public Health·Susanne BrandheimBengt Starrin
Aug 22, 2014·American Journal of Physiology. Cell Physiology·Anoop KumarPradeep K Dudeja
Jan 22, 2015·The British Journal of Nutrition·Bobbi Langkamp-HenkenWendy J Dahl
Citations
Sep 21, 2016·International Journal of Molecular Sciences·Seockmo KuHyun Ju You
Aug 14, 2018·Beneficial Microbes·M MurataK Miura
Jul 1, 2020·BMC Women's Health·Taylor C JudkinsBobbi Langkamp-Henken
Jul 1, 2017·Frontiers in Immunology·Guillermo E MarcialGraciela L Lorca
Apr 10, 2019·Nutrients·Despoina E KiousiAlex Galanis
Jan 2, 2021·Neurobiology of Stress·Elaine PattersonJuliane Hellhammer
Dec 10, 2020·Journal of Clinical Biochemistry and Nutrition·Yoshitaka HashimotoMichiaki Fukui
Jun 3, 2021·Nutrients·Laura Márquez-MoralesBeatriz Pérez-Armendáriz
Jun 17, 2021·Translational Psychiatry·Kathrin Cohen KadoshGlenn R Gibson
Jul 3, 2021·Nutrients·Annie TremblayThomas A Tompkins
Oct 20, 2021·Journal of Diabetes Investigation·Shinnosuke HataMichiaki Fukui