Bifidobacterium species lower serum glucose, increase expressions of insulin signaling proteins, and improve adipokine profile in diabetic mice

Biomedical Research
Thi Kim Chung LEXuan Da Pham

Abstract

This study, using C57BL/6J mice with streptozotocin (STZ)-induced diabetes, aimed to determine whether Bifidobacterium species (spp.) both induces the expressions of proteins in the insulin signaling pathway and enhances the expressions of certain adipocytokines. The protein expressions of IκB kinase alpha (IKKα), IκB kinase beta (IKKβ), nuclear factor-kappaB inhibitor alpha (IκBα), and the mitogen-activated protein kinase (MAPK) pathway were also investigated. Oral administration of Bifidobacterium spp. reduced blood glucose levels significantly and increased the protein expressions of insulin receptor beta, insulin receptor substrate 1, protein kinase B (Akt/PKB), IKKα, and IκBα. Extracellular-signal-regulated kinase 2 (ERK2) showed increased expression. Bifidobacterium spp. also induced the adiponectin expression and decreased both macrophage chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6) expression. In addition, IKKβ, c-Jun NH2-terminal kinase (JNK) and p38 MAP kinase expressions showed no significant changes in both groups. In conclusion, Bifidobacterium spp. may be the promising bacteria for treating diabetes.

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Citations

Nov 29, 2016·Critical Reviews in Food Science and Nutrition·Giovanna MuscogiuriAnnamaria Colao
Jan 11, 2020·Molecular Biology Reports·Rabia BhardwajHarsh Panwar
Jan 19, 2018·Critical Reviews in Food Science and Nutrition·Daniela Mayumi Usuda Prado RochaRita de Cássia Gonçalves Alfenas
May 26, 2017·São Paulo Medical Journal = Revista Paulista De Medicina·Maryam MiraghajaniReza Ghiasvand
Sep 10, 2020·Frontiers in Immunology·Jefferson Elias-OliveiraDaniela Carlos
Jan 7, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mahsa Raji LahijiFarzad Shidfar
Jun 22, 2021·Human Antibodies·Farahnaz GhaemiSeyed Davar Siadat
May 16, 2020·Current Pharmaceutical Biotechnology·Eva Alvarez-VieitesAlberto Cepeda

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