Bifunctional Au@Bi2 Se3 Core-Shell Nanoparticle for Synergetic Therapy by SERS-Traceable AntagomiR Delivery and Photothermal Treatment

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Mohsen MohammadniaeiJeong-Woo Choi

Abstract

For the first time, topological insulator bismuth selenide nanoparticles (Bi2 Se3 NP) are core-shelled with gold (Au@Bi2 Se3 ) i) to represent considerably small-sized (11 nm) plasmonic nanoparticles, enabling accurate bioimaging in the near-infrared region; ii) to substantially improve Bi2 Se3 biocompatibility, iii) water dispersibility, and iv) surface functionalization capability through straightforward gold-thiol interaction. The Au@Bi2 Se3 is subsequently functionalized for v) effective targeting of SH-SY5Y cancer cells, vi) disrupting the endosome/lysosome membrane, vii) traceable delivery of antagomiR-152 and further synergetic oncomiR knockdown and photothermal therapy (PTT). Unprecedentedly, it is observed that the Au shell thickness has a significant impact on evoking the exotic plasmonic features of Bi2 Se3 . The Au@Bi2 Se3 possesses a high photothermal conversion efficiency (35.5%) and a remarkable surface plasmonic effect (both properties are approximately twofold higher than those of 50 nm Au nanoparticles). In contrast to the siRNA/miRNA delivery methods, the antagomiR delivery is based on strand displacement, in which the antagomiR-152 is displaced by oncomiR-152 followed by a surface-enhanced Raman spectroscopy...Continue Reading

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Citations

Dec 1, 2018·Nanoscale·Jing-Jing HuXian-Zheng Zhang
Dec 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nguyễn Hoàng Ly, Sang-Woo Joo
Nov 14, 2019·Chemistry : a European Journal·Shuang ZhaoHongpeng You
Jul 28, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Zhimei He, Jun-Jie Zhu
Oct 3, 2019·Micromachines·Mohsen MohammadniaeiMin-Ho Lee
Nov 24, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Jing SunRong Cao

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