Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase

Organic Letters
Yongge Qiu, Ding Li

Abstract

[structure: see text] A bifunctional inhibitor of mevalonate kinase and mevalonate 5-diphosphate decarboxylase was synthesized. Both enzymes are in the cholesterol biosynthetic pathway and play an important role in regulating cholesterol biosynthesis. The molecule may become a useful lead compound for further development for treating cardiovascular disease and cancer. This study provides a novel example of a single inhibitor blocking two sequential steps simultaneously in the cholesterol biosynthetic pathway.

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Citations

Dec 30, 2011·Lipids in Health and Disease·Manish Rauthan, Marc Pilon
Nov 26, 2014·Protein Science : a Publication of the Protein Society·Jeffrey M VinokurJames U Bowie
Jul 12, 2014·Journal of Biomolecular Structure & Dynamics·Rajabrata BhuyanAlpana Seal
Sep 25, 2007·Bioorganic & Medicinal Chemistry Letters·Yongge QiuDing Li
Feb 7, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuyi YaoJingkang Shen
Oct 31, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Andrew Agnew, David Timson
Dec 23, 2019·RSC Medicinal Chemistry·Pimyupa ManaswiyoungkulPatrick T Gunning

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