Bifunctional MIL-53(Fe) with pyrophosphate-mediated peroxidase-like activity and oxidation-stimulated fluorescence switching for alkaline phosphatase detection

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Kun YeXiangheng Niu

Abstract

Alkaline phosphatase (ALP) is extensively used as a clinical biomarker because of its close relevance with a variety of diseases. Thus, exploring reliable and practical methods for ALP analysis is of great significance. In the present work, we explored MIL-53(Fe) as a bifunctional platform with pyrophosphate (PPi)-mediated peroxidase-like activity and oxidation-stimulated fluorescence switching for ALP sensing. The proposed MIL-53(Fe) could exhibit favorable peroxidase-mimicking activity to catalytically decompose H2O2 to hydroxyl radicals, which had strong oxidizing ability to oxidize the terephthalic acid bridging ligand, resulting in the oxidation-stimulated turn-on fluorescence of MIL-53(Fe) itself. Due to the strong coordination interaction between PPi and Fe3+, the former with a relatively large molecular structure was able to inhibit the catalytic activity of MIL-53(Fe) via capping active Fe3+ sites, leading to the suppression of its self-fluorescence response. When ALP was present, it could hydrolyze the PPi inhibitor and restore the dual functions of MIL-53(Fe) to provide fluorescence again. With the above principle, highly sensitive and selective determination of ALP with a linear scope of 2-80 U L-1 and a detection l...Continue Reading

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Sep 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanfang HeXiangheng Niu

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Citations

Sep 10, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongwei SongXiangheng Niu
May 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoyu WangHui Wei
Sep 11, 2020·Chemical Communications : Chem Comm·Xiangheng NiuYuehe Lin
Mar 16, 2021·Advanced Science·Anjaiah Nalaparaju, Jianwen Jiang
Apr 25, 2021·Advanced Materials·Weiqing XuChengzhou Zhu
May 17, 2021·Colloids and Surfaces. B, Biointerfaces·Samy M ShabanDong-Hwan Kim

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Methods Mentioned

BETA
biosensing
ESR

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