Bifunctional polyethersulfone hollow fiber with a porous, single-layer skin for use as a bioartificial liver bioreactor.

Journal of Materials Science. Materials in Medicine
Shichang ZhangYingjie Wang

Abstract

A bioartificial liver bioreactor requires a bifunctional hollow fiber that is hemocompatible on one side and cytocompatible on the other side. In this study, we developed a single-layer skin polyethersulfone (PES) hollow fiber with smooth inner surface and rough/porous outer surface for an artificial liver bioreactor. The hemocompatibility of the inner surface was evaluated by hemolysis, complement activation and clotting time. The cytocompatibility of the outer surface with HepG2 cells was examined by morphology, proliferation and liver-specific functions. The inner surface of the PES hollow fiber exhibited lower hemolysis and complement activation than cellulose acetate (CA) hollow fiber and a prolonged blood coagulation time. HepG2 cells readily adhered to the outer surfaces of the PES hollow fibers, and proliferated to form multicellular aggregates with time. Furthermore, HepG2 cells cultured on the outer surface of the PES hollow fiber exhibited higher proliferation ability and liver-specific functions than those grown on the CA hollow fiber. These results suggest that the single-layer skin PES hollow fiber is a bifunctional hollow fiber with good hemocompatibility on the inner side and cytocompatibility on the outer side....Continue Reading

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Citations

Dec 18, 2012·Tissue Engineering. Part a·Anwar Azad PalakkanT V Kumary
Mar 19, 2013·PloS One·Doreen JankeVera Jankowski
Aug 22, 2013·Journal of Materials Science. Materials in Medicine·Shichang ZhangYingjie Wang
Jul 30, 2014·Biotechnology Letters·Nelly WungMarianne J Ellis
Dec 26, 2015·Journal of Materials Science. Materials in Medicine·Xin JiangChang-Sheng Zhao
Jun 8, 2015·ACS Biomaterials Science & Engineering·Rohit S TeotiaJayesh R Bellare

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