"Big IGF-II"-induced hypoglycemia secondary to gastric adenocarcinoma

Diabetes & Metabolism
L Morbois-TrabutC Couet

Abstract

Non-islet cell tumor-related hypoglycemia is a rare phenomenon. We report the case of a 63 Year-old man admitted for hemiparesia and a capillary blood glucose of 20 mg/dL. The presence of an immature form of IGF-II that can mimic the effect of insulin, namely "big IGF-II", explained this patient's hypoglycaemia. A moderately differentiated adenocarcinoma of the cardia with metastatic extension to the stomach and the liver was demonstrated. Octreotide failed to control the hypoglycaemia, therefore prednisolone (2 mg/kg per day) and enteral feeding prevented new episodes of severe hypoglycaemia.

References

Aug 1, 1986·Postgraduate Medical Journal·I C MacdougallB M Frier
Sep 2, 1999·The New England Journal of Medicine·M J SecklJ R Seckl

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Citations

Mar 20, 2008·World Journal of Gastroenterology : WJG·Roberto DíazMaria Martín
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Timothy W BodnarMassimo Pietropaolo
Feb 23, 2019·Journal of the Endocrine Society·Ramón G De Los Santos-AguilarNicole M Iñiguez-Ariza
Nov 19, 2021·The Journal of Clinical Endocrinology and Metabolism·Pedro Marques, Márta Korbonits

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