Biglycan overexpression on tooth enamel formation in transgenic mice.

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Xin WenMichael L Paine

Abstract

Previously, it was shown that the volume of forming enamel of molar teeth in biglycan-null mice was greater than that in genetically matched wild-type mice. This phenotypic change appeared to result from an increase in amelogenin expression, implying that biglycan directly influences amelogenin synthesis. To determine whether biglycan overexpression resulted in decreased amelogenin expression, we engineered transgenic mice to overexpress biglycan in the enamel organ epithelium. Biglycan overexpression did not significantly affect the amelogenin expression in incisor and molar teeth in 3-day postnatal transgenic mice. In the transgenic animals, we observed that the immature and mature enamel appeared normal. These results suggested that increasing the biglycan expression, in the cells that synthesize the precursor protein matrix for enamel, has a negligible influence on amelogenesis.

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Citations

Jun 10, 2010·The Journal of Biological Chemistry·Rodrigo S LacruzMichael L Paine
Oct 14, 2010·Journal of Dental Research·Y-H P ChunJ P Simmer
Apr 28, 2012·PloS One·Rodrigo S LacruzBernhard Ganss
Sep 19, 2009·Regenerative Medicine·Samantha Traphagen, Pamela C Yelick
Oct 10, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rodrigo S LacruzMichael L Paine
May 4, 2012·Biomaterials·Samantha B TraphagenPamela C Yelick
Jul 7, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Vardit KramMarian F Young

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