Biglycan promotes the chemotherapy resistance of colon cancer by activating NF-κB signal transduction

Molecular and Cellular Biochemistry
Bin LiuXiaojing Xing

Abstract

Biglycan (BGN) is overexpressed in cancer stem cells of colon cancer and induces the activation of NF-κB pathway which contributes to the chemotherapy resistance of diverse cancer types. Therefore, we hypothesized that the overexpression of BGN also promoted the development of multiple drug resistance (MDR) in colon cancer via NF-κB pathway. The expression of BGN was bilaterally modulated in colon cancer cell lines HT-29 and SW-480 and the effect of treatments on the cell proliferation and resistance to 5-FU was assessed. Moreover, the role of NF-κB signaling in the BGN-mediated formation of MDR was further investigated by subjecting BGN-overexpressed SW-480 cells to the co-treatment of chemo-agents and NF-κB inhibitor, PDTC. The inhibition of BGN expression decreased the proliferation potential of HT-29 cells while the induction of BGN expression increased the potential of SW-480 cells. BGN knockdown increased HT-29 cells' sensitivity to 5-FU, represented by the lower colony number and higher apoptotic rate. To the contrary, BGN overexpression promoted the resistance of SW-480 cells to 5-FU. The effect of BGN modulation on colon cancer cells was associated with the changes in apoptosis and NF-κB pathways: BGN inhibition increa...Continue Reading

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Citations

Jul 18, 2019·International Urogynecology Journal·Ilaha IsaliSherif A El-Nashar
Jul 25, 2019·Frontiers in Cell and Developmental Biology·Sameera NallanthighalDong-Joo Cheon
Jan 18, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·WeiHua YinHongMei Xia
Apr 17, 2019·Molecular and Cellular Biochemistry·Xueyi WuLizhi Wang
Aug 23, 2020·International Journal of Molecular Sciences·Jinfen WeiHongli Du
Oct 29, 2020·Journal of Experimental & Clinical Cancer Research : CR·Longgang WangLei Zhou
Mar 17, 2021·ACS Biomaterials Science & Engineering·Hyun Jin LeePilnam Kim
Jun 29, 2021·Molecular and Cellular Biochemistry·Sandeep AppunniAlpana Sharma
Jul 24, 2021·International Journal of General Medicine·Changming ShaoBing Chen
Aug 28, 2021·Journal of Mammary Gland Biology and Neoplasia·Gina ReyeHonor J Hugo
Dec 11, 2021·Frontiers in Oncology·Lu DengRu Zhang

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Methods Mentioned

BETA
PCR
electrophoresis
FACS
flow cytometry

Software Mentioned

- Pro Analyzer
Graphpad Prism
Gel
GraphPad

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