Bilateral amblyopia after a short period of reverse occlusion in kittens

Nature
K M Murphy, Donald E Mitchell

Abstract

The majority of neurones in the visual cortex of both adult cats and kittens can be excited by visual stimulation of either eye. Nevertheless, if one eye is deprived of patterned vision early in life, most cortical cells can only be activated by visual stimuli presented to the nondeprived eye and behaviourally the deprived eye is apparently useless. Although the consequences of monocular deprivation can be severe, they can in many circumstances be rapidly reversed with the early implementation of reverse occlusion which forces the use of the initially deprived eye. However, by itself reverse occlusion does not restore a normal distribution of cortical ocular dominance and only promotes visual recovery in one eye. In an effort to find a procedure that might restore good binocular vision, we have examined the effects on acuity and cortical ocular dominance of a short, but physiologically optimal period of reverse occlusion, followed by a period of binocular vision beginning at 7.5 weeks of age. Surprisingly, despite the early introduction of binocular vision, both eyes attained acuities that were only approximately 1/3 of normal acuity levels. Despite the severe bilateral amblyopia, cortical ocular dominance appeared similar to t...Continue Reading

References

Jan 1, 1978·The Journal of Physiology·F Giffin, D E Mitchell
Nov 1, 1977·The Journal of Comparative Neurology·D E MitchellJ A Movshon
Jul 1, 1975·The Journal of Physiology·C Blakemore, R C Van Sluyters
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Nov 1, 1963·Journal of Neurophysiology·T N WIESEL, D H HUBEL

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Citations

Jan 1, 1991·Vision Research·K M Murphy, D E Mitchell
Oct 13, 2000·The European Journal of Neuroscience·G T PruskyR M Douglas
Jan 22, 2003·The European Journal of Neuroscience·Glen T Prusky, Robert M Douglas
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·D E MitchellP C Kind
Dec 11, 1997·Journal of Chemical Information and Computer Sciences·W Y ChoyG Zhu
Feb 11, 2015·Vision Research·Kate WilliamsKathryn M Murphy
Mar 29, 2002·Nature·Peter C KindFrank Sengpiel
Dec 16, 2005·Journal of Neurophysiology·Stuart D FaulknerFrank Sengpiel
Jan 1, 1989·Experimental Brain Research·R S HarwerthG K von Noorden
Oct 1, 2019·Neural Plasticity·Justin L BalsorKathryn M Murphy
May 17, 2003·European Journal of Ophthalmology·C NucciG Bagetta
Nov 17, 2020·Frontiers in Cellular Neuroscience·Justin L BalsorKathryn M Murphy

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