PMID: 9532544Apr 9, 1998Paper

Bilateral anterior ischemic optic neuropathy following influenza vaccination

Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
A KawasakiR Tang

Abstract

Optic neuritis is an occasional complication of vaccination. Visual loss can be unilateral or bilateral, and most patients recover substantially without treatment. The presumptive mechanism is an immune-mediated demyelinating injury of the optic nerve. We report two patients who had permanent visual loss following influenza vaccination. Their pattern of visual loss, segmental optic disc changes, and failure of visual recovery were atypical for demyelinating optic neuritis and reminiscent of a primary ischemic injury to the optic nerve. We speculate that an immune complex-mediated vasculopathy following vaccination can cause anterior ischemic optic neuropathy. Clinicians should be aware of this entity because of the less favorable prognosis for visual recovery in these cases.

Citations

Jan 5, 2002·Ophthalmology·John B KerrisonRenata M Engler
Apr 2, 2013·Autoimmunity Reviews·Joerg-Patrick Stübgen
Oct 18, 2014·Expert Opinion on Drug Safety·Miguel Cordero-ComaTaygan Yilmaz
Nov 4, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·William HuynhChris Dedousis
Dec 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C M BatesA Quan
Apr 29, 2016·Seminars in Ophthalmology·David PapkeLeanne T Labriola
Mar 12, 2020·Ocular Immunology and Inflammation·Leonardo Ferreira JorgeDaniel Vítor Vasconcelos-Santos

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