PMID: 8939466Oct 25, 1996Paper

Bilateral biochemical and biophysical retinal changes after unilateral ocular trauma in the mouse

Neuroscience Letters
W L LamD T Yew

Abstract

The bilateral response of the mouse retinae after puncture and insertion of iron wire in one eye was studied by electrophoretic analysis of protein changes and free radicals quantitation at 4, 15 and 42 days after surgery. The effect of cyclosporine was also studied. Several low molecular weight (< 24 kDa) polypeptide subunits were detected in both the traumatized and contralateral eyes of experimental animals. Free radical levels rose in both traumatized and contralateral eyes although the extent was much greater in the former. Both biochemical and biophysical assays showed that treatment with cyclosporine was effective in suppressing the responses in retinal proteins and free radicals only for up to 15 days. These results substantiated our earlier report that unilateral injury to one eye with retention of the foreign body affects both eyes in the mouse.

References

Nov 1, 1979·Survey of Ophthalmology·G E Marak
Nov 30, 1973·Biochimica Et Biophysica Acta·V E KaganY P Kozlov
Sep 1, 1984·Archives of Ophthalmology·H K Müller-HermelinkW Daus

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Citations

Oct 4, 2015·Progress in Retinal and Eye Research·Helen V Danesh-MeyerColin R Green
May 5, 2005·The European Journal of Neuroscience·L PanagisC R Dermon
Feb 24, 2015·Neuroscience Letters·Vanessa K Avellaneda-ChevrierBalwantray C Chauhan
Dec 24, 2008·Neuroreport·Tamar MacharadzeMichael R Kreutz
Nov 17, 2019·International Journal of Molecular Sciences·Fernando Lucas-RuizMarta Agudo-Barriuso

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