Bilateral carotid sinus nerve transection exacerbates morphine-induced respiratory depression

European Journal of Pharmacology
Santhosh M BabyStephen J Lewis

Abstract

Opioid-induced respiratory depression (OIRD) involves decreased sensitivity of ventilatory control systems to decreased blood levels of oxygen (hypoxia) and elevated levels of carbon dioxide (hypercapnia). Understanding the sites and mechanisms by which opioids elicit respiratory depression is pivotal for finding novel therapeutics to prevent and/or reverse OIRD. To examine the contribution of carotid body chemoreceptors OIRD, we used whole-body plethysmography to evaluate hypoxic (HVR) and hypercapnic (HCVR) ventilatory responses including changes in frequency of breathing, tidal volume, minute ventilation and inspiratory drive, after intravenous injection of morphine (10 mg/kg) in sham-operated (SHAM) and in bilateral carotid sinus nerve transected (CSNX) Sprague-Dawley rats. In SHAM rats, morphine produced sustained respiratory depression (e.g., decreases in tidal volume, minute ventilation and inspiratory drive) and reduced the HVR and HCVR responses. Unexpectedly, morphine-induced suppression of HVR and HCVR were substantially greater in CSNX rats than in SHAM rats. This suggests that morphine did not compromise the function of the carotid body-chemoafferent complex and indeed, that the carotid body acts to defend against ...Continue Reading

Citations

Oct 17, 2019·Annual Review of Physiology·Patricia Ortega-Sáenz, José López-Barneo
Jan 5, 2021·Frontiers in Physiology·Paulina M GetsyStephen J Lewis
Dec 18, 2020·Frontiers in Physiology·Patricia Ortega-SáenzJosé López-Barneo
Jun 24, 2020·Peptides·Richard J Bodnar
Apr 8, 2021·Journal of Neurophysiology·Jan-Marino RamirezErica S Levitt
Jun 6, 2021·British Journal of Pharmacology·Jordan T BatemanErica S Levitt
Jul 13, 2021·Frontiers in Pharmacology·Santhosh BabyStephen Lewis
Sep 8, 2021·Frontiers in Physiology·Michael D Sunshine, David D Fuller
Oct 26, 2021·Frontiers in Physiology·Isato FukushiYasumasa Okada

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