Bilateral Chilblain-like Lesions of the Toes Characterized by Microvascular Remodeling in Adolescents During the COVID-19 Pandemic.

JAMA Network Open
Valentina DiscepoloMaria Alessio

Abstract

Chilblain-like lesions have been one of the most frequently described cutaneous manifestations during the COVID-19 pandemic. Their etiopathogenesis, including the role of SARS-CoV-2, remains elusive. To examine the association of chilblain-like lesions with SARS-CoV-2 infection. This prospective case series enrolled 17 adolescents who presented with chilblain-like lesions from April 1 to June 30, 2020, at a tertiary referral academic hospital in Italy. Macroscopic (clinical and dermoscopic) and microscopic (histopathologic) analysis contributed to a thorough understanding of the lesions. Nasopharyngeal swab, serologic testing, and in situ hybridization of the skin biopsy specimens were performed to test for SARS-CoV-2 infection. Laboratory tests explored signs of systemic inflammation or thrombophilia. Structural changes in peripheral microcirculation were investigated by capillaroscopy. Of the 17 adolescents (9 [52.9%] male; median [interquartile range] age, 13.2 [12.5-14.3] years) enrolled during the first wave of the COVID-19 pandemic, 16 (94.1%) had bilaterally localized distal erythematous or cyanotic lesions. A triad of red dots (16 [100%]), white rosettes (11 [68.8%]), and white streaks (10 [62.5%]) characterized the der...Continue Reading

References

Mar 19, 2020·The New England Journal of Medicine·Xiaoxia LuUNKNOWN Chinese Pediatric Novel Coronavirus Study Team
Apr 20, 2020·Journal of the American Academy of Dermatology·Angelo Valerio MarzanoPiergiacomo Calzavara-Pinton
May 8, 2020·Journal of the American Academy of Dermatology·Adèle de MassonUNKNOWN SNDV (French National Union of Dermatologists-Venereologists)
May 15, 2020·Cell Host & Microbe·Zhuo ZhouJianwei Wang
Jun 2, 2020·Journal of the American Academy of Dermatology·Esther E FreemanUNKNOWN American Academy of Dermatology Ad Hoc Task Force on COVID-19
Jun 5, 2020·Journal of the American Academy of Dermatology·Diego Fernandez-NietoDaniel Ortega-Quijano
Jun 14, 2020·Journal of the American Academy of Dermatology·Cristiana ColonnaAngelo Valerio Marzano
Jun 25, 2020·Journal of Foot and Ankle Research·Ivan R Bristow, Alan M Borthwick
Jun 26, 2020·JAMA Dermatology·Anne HermanMarie Baeck
Sep 23, 2020·JAMA : the Journal of the American Medical Association·Kanade Shinkai, Anna L Bruckner
Oct 7, 2020·JAAD Case Reports·Gabriella FabbrociniAlfredo Guarino
Oct 20, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Marie Baeck, Anne Herman
Nov 25, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Giovanni GenoveseAngelo Valerio Marzano

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Citations

Aug 17, 2021·Dermatologic Therapy·Uwe WollinaRobert Baran

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Software Mentioned

GraphPad
DermaView
GraphPad Prism

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