Bilateral cleft lip and palate: A morphometric analysis of facial skeletal form using cone beam computed tomography

Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists
John M StarbuckKatherine S Kula

Abstract

Bilateral cleft lip and palate (BCLP) is caused by a lack of merging of maxillary and nasal facial prominences during development and morphogenesis. BCLP is associated with congenital defects of the oronasal facial region that can impair ingestion, mastication, speech, and dentofacial development. Using cone beam computed tomography (CBCT) images, 7- to 18-year old individuals born with BCLP (n = 15) and age- and sex-matched controls (n = 15) were retrospectively assessed. Coordinate values of three-dimensional facial skeletal anatomical landmarks (n = 32) were measured from each CBCT image. Data were evaluated using principal coordinates analysis (PCOORD) and Euclidean Distance Matrix Analysis (EDMA). PCOORD axes 1-3 explain approximately 45% of the morphological variation between samples, and specific patterns of morphological differences were associated with each axis. Approximately, 30% of facial skeletal measures significantly differ by confidence interval testing (α = 0.10) between samples. While significant form differences occur across the facial skeleton, strong patterns of differences are localized to the lateral and superioinferior aspects of the nasal aperture. In conclusion, the BCLP deformity significantly alters ...Continue Reading

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Citations

Oct 21, 2016·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Sung-Hwan ChoiChung-Ju Hwang
Nov 16, 2017·Plastic and Reconstructive Surgery·Woo Shik JeongJong Woo Choi
Sep 27, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Kristyna Ceuninck, John M Starbuck
Sep 12, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Yaser Ahmad, John M Starbuck
Mar 10, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Nicole Santana, John M Starbuck
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Nov 2, 2019·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Shabnam AjamiRoya Afshinpoor
Apr 18, 2018·American Journal of Medical Genetics. Part a·Charles ZhangSeth M Weinberg

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